Synthesis and Anti-Inflammatory Activity of 2-{[5-(2-Chlorophenyl)-4H-1,2,4-Triazol- 3-YL]Sulfanyl}-1-(Substituted Phenyl)Ethanones

doi:10.1007/s11094-017-1654-8

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Synthesis and Anti-Inflammatory Activity of 2-{[5-(2-Chlorophenyl)-4H-1,2,4-Triazol- 3-YL]Sulfanyl}-1-(Substituted Phenyl)Ethanones

Published Oct 1, 2017 · N. Karande, L. Rathi

Pharmaceutical Chemistry Journal

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Abstract

With the aim of obtaining potential anti-inflammatory compounds, 2-{[5-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-(phenyl)ethanone and a series of its derivatives were synthesized, purified by flash chromatography, and characterised by spectral and elemental analysis. All the new synthesized compounds were evaluated for their anti-inflammatory activity using carrageenan-induced paw edema test on Wistar albino rats. The results suggest that 1-(4-fluorophenyl)-2-{[5-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone 7l exhibit remarkable activity when compared with indomethacin even in the absence of carboxyl group in its structure, which reduces the possibility of gastric irritation.

Study Snapshot

2-[5-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl-1-(phenyl)ethanone 7l shows remarkable anti-inflammatory activity compared to indomethacin, with reduced gastric irritation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and Anti-Inflammatory Activity of 2-{[5-(2-Chlorophenyl)-4H-1,2,4-Triazol- 3-YL]Sulfanyl}-1-(Substituted Phenyl)Ethanones

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