Paper
Synthesis, Antimicrobial and Antiinflammatory Activities of 1,3,4‐Oxadiazoles Linked to Naphtho[2,1‐b]furan.
Published Nov 1, 2006 · K. C. Ravindra, H. Vagdevi, V. P. Vaidya
ChemInform
15
Citations
0
Influential Citations
Abstract
Condensation of naphtho[2,1-b]furan-2-carboxyhydrazide 1 with different aromatic aldehydes affords the corresponding N 1 -[(1E)-arylmethylene]-naphtho[2,1-b]furan-2-carboxyhydrazides 2a-h. These compounds undergo cyclization with acetic anhydride and mercuric oxide to yield 3-acetyl-5-naphtho[2,l-b]furan-2-yl-2-aryl-2,3-dihydro-1,3,4-oxadiazoles 3a-h and 2-naphtho[2,1-b]furan-2-yl-5-aryl-1,3,4-oxadiazoles 4a-h respectively. The compound 1 on refluxing with carbon disulphide and ethanolic potassium hydroxide followed by acidification with hydrochloric acid furnishes 5-naphtho[2,1-b]furan-2-yl-1,3,4-oxadiazole-2(3H)-thione 5. It is converted into Mannich bases 3-(anilinomethyl)-5-naphtho[2,1-b]furan-2-y]-1,3,4-oxadiazole-2(3H)-thiones 6a-h on treatment with formaldehyde and appropriate aromatic amines. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The selected compounds have been screened for their antimicrobial and anti-inflammatory activities.
Naphtho[2,1-b]furan-linked 1,3,4-oxadiazoles show antimicrobial and anti-inflammatory properties when synthesized and characterized by elemental analysis and spectral studies.
Full text analysis coming soon...