Synthesis and Antiulcer Activity Study of 1,4-Dihydropyridines and Their Mannich Bases with Sulfanilamide.

doi:10.1002/CHIN.200938133

Paper

Synthesis and Antiulcer Activity Study of 1,4-Dihydropyridines and Their Mannich Bases with Sulfanilamide.

Published May 1, 2009 · B. B. Subudhi, P. Panda, D. Bhatta

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Abstract

3,5-Diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)-pyridines 1a-e are prepared following Hantzsch pyridine synthesis by condensation of ethyl acetoacetate with different aromatic aldehydes in presence of ammonium hydroxide. Compounds 1a-e on reaction with paraformaldehyde and sulfanilamide yielded 3,5-diethoxycarbonyl-1-[(4'-sulfamoyl-1'-amino methyl) phenyl]-1,4-dihydro-2,6-dimethyl-4-(substituted)-pyridines 2a-e. The antiulcer activities have been performed by estimating volume of gastric acid, pH, free acidity, total acidity and ulcer index. The antiulccr activity of 1,4-dihydropyridines is enhanced significantly on conjunction with sulfanilamide. Substitution of methoxy group increased the antiulcer potential of the compounds.

In Vitro Study

Study Snapshot

1,4-dihydropyridines show enhanced antiulcer activity when combined with sulfanilamide, with methoxy group substitution increasing the potential.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and Antiulcer Activity Study of 1,4-Dihydropyridines and Their Mannich Bases with Sulfanilamide.

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