Paper
Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents
Published Dec 8, 2012 · B. M. Kalshetty, R. Gani, M. B. Kalashetti
Global Journal of Science Frontier Research
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Abstract
The derivatives of Indole show biological activities including herbicidal. The newly synthesized compounds 1- phenylethyl,2-methyl,3-ethoxy carbonyl,5-methoxycarbonyl ,2- methoxy Indole (Compound 2) were prepared by treating 1- phenyl,3-ethoxycarbonyl,5-hydroxy,2-methyl Indole (Com- pound 1) successively with methyl bromo- acetate and refluxing with K2CO3 / KI in the presence of dry acetone. Newly synthesized compound 2 refluxed with hydrazine hydrate in alcoholic media forming 1-Phenylethyl,3-ethoxy carbonyl,2-methyl Indole,5-yl oxy acetic acid hydrizide (Compound 3). This drug which on separately reacting with carbon disulphide, phenyl iso-thiocynide, acetylacetone, triethylorthoformate gave condensed bridge head heterocyclic's such as 1-Phenyl ethyl,2-methyl,3-ethoxy cabonyl,5(5'-mercapto,1'-3'-4'-oxadiazol,2'-yl )-methoxy Indole (Compound 4), 1-Phenylethyl,3-ethoxycarbonyl,2-methyl,5-yl (methoxy carbothisemi cabazide) (Compound 5), 1-Phenyl,2- methyl,3-ethoxycarbonyl,5(2,5, dimethyl Pyrrole,1-yl) amino carbonyl methoxy Indole (Compound 8) and 1-Phenyl,3- ethoxycarbonyl,2 - methyl,5 - (1',3',4' - oxadiazole,2'-yl-methoxy Indole (Compound 9) respectively. Compound 6 and Compound 7 were also synthesized heterocycles of the Indole derivatives. The structures of the compounds were established with the help of the elemental analysis and spectral date (IR, NMR and Mass). Compounds were screened for their antimicrobial potential.
New 1-phenyl, 3-ethoxycarbonyl, 5-hydroxy Indole derivatives show potential as antimicrobial agents and herbicidal agents.
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