Paper
Synthesis of 6-Chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile: A Novel, Versatile Intermediate for the Synthesis of Trifluoromethylated Azaindazole Derivatives
Published May 2, 2019 · Manjunath Channapur, R. Hall, J. Kessabi
Synlett
Q3 SJR score
3
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0
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Abstract
Abstract A synthesis of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile, a versatile building block for the synthesis of trifluoromethylated N-heterocycles, is described. The reactions of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile with 1,2- and 1,3-bisnucleophiles were investigated.
Study Snapshot
6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile is a versatile intermediate for the synthesis of trifluoromethylated N-heterocycles, offering a new approach for the synthesis of trifluoromethylated azaindazole derivative
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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