Paper
Synthesis, Characterization and Anticancer Activity of 5-Substituted 4,5,6,7-Tetrahydro- N-(tetrahydro-2H-pyran-4-yl)thieno[3,2-c]pyridine-2-carboxamide Derivatives
Published 2018 · N. Rao, M. V. B. Rao, K. Prasad
Asian Journal of Chemistry
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Abstract
4,5,6,7-Tetrahydrothieno-pyridine (THTP) represents a widely used lead structure with multitude of interesting applications in numerous pharmacological fields. Thus, various biological activities such as antimicrobial activity [1-15], antileishmanial activity [16], antiarrhythmic activity [17], antiinflammatory activity [18-22], antihyperlipidemic activity [23], antidepressant activity [24], anticancer activity [25,26], antiplatelet activity [27,28], antidiabetic [29-31] and antituberculosis activity [32,33] have been reported and explored till date. Fusion of other nuclei like benzene, indole, oxadiazole, triazole rings to THTP nucleus enhances the pharmacological activities than its parent nucleus. The incorporation of benzylic or substituted benzylic groups on the nitrogen of the thienopyridine ring can bring an extensive modification in the biological activities of parent compound [34-36]. Hence, different substitutions at nitrogen of the biological activity of the new chemical entities (NCEs). The present study describes the synthesis, characterization and Synthesis, Characterization and Anticancer Activity of 5-Substituted 4,5,6,7-TetrahydroN-(tetrahydro-2H-pyran-4-yl)thieno[3,2-c]pyridine-2-carboxamide Derivatives
5-Substituted 4,5,6,7-TetrahydroN-(tetrahydro-2H-pyran-4-yl)thieno[3,2-c]pyridine-2-carboxamide derivatives show promising anticancer activity, with potential applications in various pharmacological fields.
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