SYNTHESIS, CRYSTAL STRUCTURE AND BIOLOGICAL ACTIVITY OF BIS(ACETONE THIOSEMICARBAZONE-S)DICHLORODIPHENYLTIN(IV)

doi:10.1039/a605679b

Paper

SYNTHESIS, CRYSTAL STRUCTURE AND BIOLOGICAL ACTIVITY OF BIS(ACETONE THIOSEMICARBAZONE-S)DICHLORODIPHENYLTIN(IV)

Published 1997 · S. Teoh, S. Ang, S. Teo

Journal of The Chemical Society-dalton Transactions

UNKNOWN SJR score

35

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Abstract

The reaction between diphenyltin(IV) dichloride and thiosemicarbazide using acetone–ethanol as solvent resulted in the formation of bis(acetone thiosemicarbazone-S)dichlorodiphenyltin(IV), SnPh 2 Cl 2 (atsc) 2 . The crystal structure determination of the compound revealed it to be a monomeric six-co-ordinated organotin(IV) complex. Each of the two atsc functions as a monodentate ligand, co-ordinating to the tin atom through the sulfur atom and conferring a distorted-octahedral geometry upon the tin. The Sn–S bond length is 2.712(1) A. The antifungal activity of the complex, atsc and SnPh 2 Cl 2 against four plant pathogens has been evaluated. The complex displays marked fungitoxicity against these fungi and is more fungitoxic than free atsc and SnPh 2 Cl 2 . It has also shown significant cytotoxicity against human colon adenocarcinoma, breast adenocarcinoma, hepatocellular carcinoma and acute lymphoblastic leukaemia.

Study Snapshot

The compound bis(acetone thiosemicarbazone-S)dichlorodiphenyltin(IV) shows significant antifungal activity against plant pathogens and significant cytotoxicity against human cancers.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

SYNTHESIS, CRYSTAL STRUCTURE AND BIOLOGICAL ACTIVITY OF BIS(ACETONE THIOSEMICARBAZONE-S)DICHLORODIPHENYLTIN(IV)

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