2,2-Bis(chloromethyl)-5,5-dimethyl-1,3-dioxane 
 
 
 
 
2-Cyclopenten-1-one 
 
 
 
 
6,6-Dimethyl-1-methylene-4,8-dioxaspiro[2.5]octane 
 
 
 
 
1,6,6-Trimethyl-4,8-dioxaspiro[2.5]oct-1-ene 
 
 
 
 
 
Keywords: 
 
substituted cyclopropenone acetal; 
alkylidene cyclopropanone acetal; 
dipolar trimethylenemethane; 
cycloaddition; 
cysteine protease inhibitor; 
biological activity; 
cycloadditions; 
electron acceptors

Cycloaddition of 2,2'-dialkoxy-1'-methylenecyclopropane to 1,6,6-Trimethyl-4,8-dioxaspiro[2.5]octane leads to a cysteine protease inhibitor with biological activity.

Organic Syntheses

Synthesis and [3 + 2] Cycloaddition of a 2,2‐Dialkoxy‐1‐Methylenecyclopropane: 6,6‐Dimethyl‐1‐Methylene‐4,8‐Dioxaspiro[2.5]octane and cis‐5‐(5,5‐Dimethyl‐1,3‐Dioxan‐2‐ylidene)Hexahydro‐1(2H)‐Pentalen‐2‐one

Paper

Synthesis and [3 + 2] Cycloaddition of a 2,2‐Dialkoxy‐1‐Methylenecyclopropane: 6,6‐Dimethyl‐1‐Methylene‐4,8‐Dioxaspiro[2.5]octane and cis‐5‐(5,5‐Dimethyl‐1,3‐Dioxan‐2‐ylidene)Hexahydro‐1(2H)‐Pentalen‐2‐one

References

Citations