Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds.

doi:10.1016/j.bmcl.2013.06.001

Paper

Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds.

Published Aug 1, 2013 · Wen Chen, Xiaoqing Deng, Yan Li

Bioorganic & medicinal chemistry letters

Q2 SJR score

34

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Abstract

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In Vitro Study

Study Snapshot

Novel hybrid compounds of 2-phenyl-3-alkylbenzofuran and imidazole/triazole show potent cytotoxic activity against human tumor cell lines, with hybrid compound 31 showing the most potent selective activity against breast and colon carcinomas.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds.

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