Paper
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones.
Published Feb 15, 2005 · L. Deady, M. Rogers, L. Zhuang
Bioorganic & medicinal chemistry
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39
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Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Carboxamide derivatives of benzo[b][1,6]naphthyridine-5H]ones show potent cytotoxicity against leukemia and lung carcinoma, with the 2-(4-fluorophenyl) derivative showing curative activity against colon 38 tumors in mice.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
Carboxamide derivatives of benzo[b][1,6]naphthyridines show potent cytotoxic activity against leukemia and lung cancer cells, with some showing curative effects in a mouse model of colon 38 tumors.
2003·47citations·L. Deady et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents.
Novel angular benzophenazines show potential as potent anticancer agents by targeting DNA topoisomerase I and II, potentially circumventing multidrug resistance mechanisms in cancer chemotherapy.
2002·111citations·N. Vicker et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
The reaction of homophthalic acid and some aza analogues with vilsmeier reagent: a reinvestigation
Homophtalic acid and its aza analogues can produce novel quinolizinium species by reacting with vilsmeier reagent, with novel products such as 7-(3-carboxypyridin-2-yl)quinolizinium-1-carboxylate inner salt (1
2001·17citations·L. Deady et al.·Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry
Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer.
ZD1839 is an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor with potential for clinical use in treating cancer.
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Bioorganic & medicinal chemistry letters
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
DACA and selected acridine-substituted analogues show potential as anticancer drugs, with steric bulk being crucial for activity, and both show activity in the refractory subcutaneous colon 38 tumor model.
1997·60citations·J. A. Spicer et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Citations
One‐Pot Multicomponent Synthesis of Substituted 1,6‐Naphthyridine Derivatives Employing 4‐Aminocumarin
This study successfully synthesized 1,6-naphthyridine with high efficiency using a multicomponent reaction, demonstrating rapid reactions, high yields, and straightforward separation of catalyst and product from the reaction mixture.
2024·1citation·E. Ezzatzadeh et al.·Applied Organometallic Chemistry
Applied Organometallic Chemistry
Microwave-assisted one-pot two-step imine formation-hetero-Diels-Alder-detosylation/aromatization sequence: direct access to dibenzo[b,h][1,6]naphthyridines.
Microwave-assisted, copper-catalyzed, one-pot, two-step reaction provides high yields of functionalized [1,6]naphthyridines in a single synthetic operation, with tolerance for various electron-donating and electron-withdrawing substituents.
2022·2citations·G. Jan et al.·Organic & biomolecular chemistry
Organic & biomolecular chemistry
Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines
Recent synthetic developments have led to a wide range of functionalized 1,6-naphthyridines with potential anticancer properties, highlighting their importance in synthetic and medicinal chemistry fields.
2021·11citations·M. Lavanya et al.·Topics in Current Chemistry
Topics in Current Chemistry
Antiproliferative Activity of N-Substituted 2,4-Diamino-5-Aryl-5,6,7,8,9,10-Hexahydrobenzo[B][1,8]Naphthyridine-3-Carbonitriles
N-substituted 2,4-diamino-5-aryl-5,6,7,8,9,10-hexahydrobenzo[B][1,8]naphthyridine-3-carbonitriles show antiproliferative activity, with compounds with a
2020·1citation·I. N. Bardasov et al.·Pharmaceutical Chemistry Journal
Pharmaceutical Chemistry Journal
Studying the effect of particle size on the antibacterial activity of some N-nicotinyl phosphoric triamides
Nanoparticles of N-nicotinyl phosphoric triamides show stronger antibacterial activity than their macroscaled analogues, with the most significant effect observed for macrosized 1.
2019·3citations·N. Oroujzadeh et al.·Particulate Science and Technology
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Synthesis of novel benzo[ b ]pyrimido[4',5':5,4]thieno[2,3-e][1,6]naphthyridine-8-ones via Pictet-Spengler cyclization
This study presents an efficient method for synthesis of novel benzo[b]pyrimido[4′,5′:5,4]thieno[2,3-e][1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization, yield
2016·5citations·Daolin Wang et al.·Chinese Chemical Letters
Chinese Chemical Letters
An efficient synthesis of novel benzo[b]pyrido[3′,2′:4,5]thieno[2,3-e][1,6]naphthy-ridine-8-ones
This study developed an efficient method for synthesis of novel benzo[b]pyrido[3′,2′:4,5]thieno[2,3-e][1,6] naphthyridine-8-one derivatives using a Pictet-Spengler reaction between aromatic aldeh
2015·4citations·Daolin Wang et al.·Chinese Chemical Letters
Chinese Chemical Letters