Paper

Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.

Published Apr 2, 2021 · Ming Sun, Jiaxing Zhao, Qing Mao

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

The optimized compound, 2-(3-cyano-4-isopentoxy)phenylpyrimidine-4-ol, effectively reduces serum uric acid levels at an oral dose of 30 mg/kg, making it a promising therapy for hyperuricemia and gout.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.

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