Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H -pyran-2- carboxamide Derivatives

Paper

Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H -pyran-2- carboxamide Derivatives

Published Dec 26, 2003 · M. Aytemir, D. Erol, R. Hider

Turkish Journal of Chemistry

Q3 SJR score

49

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0

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Abstract

The synthesis of a range of 3-hydroxy-4-oxo-4H-pyran-2- carboxamide with antimicrobial activity is described. Amide derivatives of pyranone were synthesised using TBTU [2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate] as a coupling agent and NMM (N-methylmorpholine) as a base. Antimicrobial activities were determined as MIC values using the microdilution broth method against Staphylococcus aureus, Entrococcus faecalis, Escherichia coli and Pseudomonas aeruginosa for bacteria and Candida albicans, C. krusei and C. parapsilosis for fungi. 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-[N-(4'-methylcoumarin-7-yl) carboxamide] (8c) exhibited higher antibacterial activity against S. aureus, E. faecalis and E. coli than the other compounds. In addition, 8c was more active against C. krusei than the other synthesised compounds.

In Vitro Study

Study Snapshot

3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide derivatives show promising antimicrobial activity against bacteria and fungi, with 8c showing the highest activity against S. aureus, E. faecalis, and E. coli.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H -pyran-2- carboxamide Derivatives

References

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