Synthesis and biological evaluation of 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives as novel PI3Kδ inhibitors

doi:10.1016/J.CCLET.2015.05.041

Paper

Synthesis and biological evaluation of 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives as novel PI3Kδ inhibitors

Published Oct 1, 2015 · Jialong Guo, Yunyi Liu, Ya-zhong Pei

Chinese Chemical Letters

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Abstract

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In Vitro Study

Study Snapshot

These 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives show potential as novel antitumor agents by inhibiting PI3K.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives as novel PI3Kδ inhibitors

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