The synthesis and metabolism of hexadeca-4,7,10-trienoate, eicosa-8,11,14-trienoate, docosa-10,13,16-trienoate and docosa-6,9,12,15-tetraenoate in the rat.

doi:10.1016/0005-2760(68)90092-1

Paper

DOI: 10.1016/0005-2760(68)90092-1

The synthesis and metabolism of hexadeca-4,7,10-trienoate, eicosa-8,11,14-trienoate, docosa-10,13,16-trienoate and docosa-6,9,12,15-tetraenoate in the rat.

Published May 1, 1968 · H. Sprecher

Biochimica et biophysica acta

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Methyl esters can be converted to long-chain polyunsaturated fatty acids in rats on a fat-deficient diet, with some degrading and incorporation into liver lipids.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/s0021-9258(18)99567-0

Chain elongation of linoleic acid and its inhibition by other fatty acids in vitro.

Chain elongation of linoleic acid to eicosadienoic acid is most effective in liver microsomes with cofactors, NADPH, and ATP, and is inhibited by saturated and mono-unsaturated fatty acids.

1967·109citations·H. Mohrhauer et al.·The Journal of biological chemistry

The Journal of biological chemistry

DOI: 10.1016/0005-2760(67)90159-2

The total synthesis and metabolism of 7,10,13,16-docosatetraenoate in the rat.

Feeding rats with 7,10,13,16-docosatetraenoate suppresses polyunsaturated fatty acid biosynthesis and is preferentially converted to arachidonate or desaturated to 4,7,10,13,16-docosapentaenoate.

1967·55citations·H. Sprecher·Biochimica et biophysica acta

Biochimica et biophysica acta

DOI: 10.1139/O67-124

The beta-oxidative degradation of docosenoic acids to eicosenoic and octadecenoic acids in the rat.

Rats can degrade docosenoic acids to eicosenoic and oleic acids, contributing to their tissue lipid content.

1967·36citations·B. Craig et al.·Canadian journal of biochemistry

Canadian journal of biochemistry

DOI: 10.1016/0005-2760(67)90123-3

Retroconversion of polyunsaturated fatty acids in vivo by partial degradation and hydrogenation.

Retroconversion of polyunsaturated fatty acids in vivo involves partial degradation and biohydrogenation, maintaining random labeling throughout the conversion process.

1967·42citations·H. Schlenk et al.·Biochimica et biophysica acta

Biochimica et biophysica acta

DOI: 10.1016/s0021-9258(18)96419-7

Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

Polyunsaturated fatty acids activate the desaturation of palmitic, stearic, oleic, linoleic, and linolenic acids, while saturated acids have no effect on desaturation.

1966·384citations·R. R. Brenner et al.·The Journal of biological chemistry

The Journal of biological chemistry

Citations

DOI: 10.1053/j.sempedsurg.2018.07.003

A detailed guide to lipid therapy in intestinal failure.

Intravenous lipid emulsions are an essential part of nutrition therapy for intestinal failure patients, providing essential fatty acids and non-protein calories, but may carry risks like intestinal failure associated liver disease.

2018·2citations·K. Gura et al.·Seminars in pediatric surgery

Seminars in pediatric surgery

DOI: 10.1002/RECL.19710900904

Optimization, mechanism, and kinetics of the hydrogenation of skipped polyynoic acids to all‐cis skipped polyenoic acids

Hydrogenation of skipped polyynoic acids to all-cis polyenoic acids with quinoline in light petroleum, ethyl acetate, or acetone at room temperature produces 90-99% pure compounds with ene-ynoic intermediates.

2010·5citations·A. Steenhoek et al.·Recueil des Travaux Chimiques des Pays-Bas

Recueil des Travaux Chimiques des Pays-Bas

DOI: 10.1002/RECL.19720910404

The infrared spectrum of linear alkynoic acids

Linear alkynoic acids with 2-5 triple bonds show similar infrared spectra, with bands predominantly determined by the chain's middle part.

2010·0citations·A. Memelink·Recueil des Travaux Chimiques des Pays-Bas

Recueil des Travaux Chimiques des Pays-Bas

DOI: 10.1016/j.plefa.2009.05.020

The essentiality of arachidonic acid and docosahexaenoic acid.

Fish oil-based lipid emulsions containing AA and DHA alone can prevent essential fatty acid deficiency, suggesting they may be the true essential fatty acids.

2009·158citations·Hau D. Le et al.·Prostaglandins, leukotrienes, and essential fatty acids

Prostaglandins, leukotrienes, and essential fatty acids

DOI: 10.1139/H07-034

Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements.

In adults, only 5% of ALA is converted to EPA and 0.5% to DHA, despite their potential health benefits.

2007·551citations·M. Plourde et al.·Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme