Synthesis of 5S and 4S RNA in Metaphase-Arrested HeLa Cells
E. Zylber, S. Penman
May 28, 1971
Citations
48
Citations
Journal
Science
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Semantic Scholar
Key Takeaway Key Takeaway: Metaphase-arrested HeLa cells continue to synthesize both 5S and 4S RNA at approximately 74% of the interphase rate, with 4S RNA synthesized at approximately one-third the rate.
Abstract
The continued synthesis of both 5S and 4S RNA in metaphase-arrested HeLa cells is demonstrated; 5S RNA is apparently synthesized at approximately 74 percent of the interphase rate, while 4S RNA is synthesized at approximately one-third the rate. The ratio of uridine incorporation to RNA methylation is used to correct for the alteration in the specific activity of the pyrimidine pool during metaphase arrest.
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