Paper
Synthesis, SAR, Molecular Docking and Antituberculosis Study of 3-Methyl-1-Benzofuran-2-Carbohydrazide
Published 2016 · B. Thorat, Bhusan Nazirkar, V. Thorat
Asian Journal of Chemistry
5
Citations
0
Influential Citations
Abstract
Most of the benzofuran compounds [1,2] frequently occur in natural products and are good chelating agents. The compound amiodarone hydrochloride used as an ideal antiarrhythmic drug [3] contains a 2,3-substituted benzofuran moiety. The synthesis of ester of 1-benzofuran-2-carboxylate derivatives was reported by number of scientists. They can be synthesized by direct condensation of 2-hydroxybenzophenones with ethyl 2-bromoacetate in dry toluene in the presence of sodium hydride, sodium ethoxide in refluxing absolute ethanol [4]. 1-Benzofuran-2-carbohydrazide has been synthesized from salicylaldehyde and ethyl chloroacetate [5]. 5-Chlorobenzofuran-2-carbohydrazide [6] were synthesized from ethyl 5chlorobenzofuran-2-caboxylate and condensed with various substituted aromatic aldehyde to give Schiff base. 5-Bromosalicylaldehyde was treated with hydroxylamine hydrochloride in N,N-dimethyl formamide under reflux conditions forming 5-bromo salicylonitrile which is further treated with ethyl chloroacetate in anhydrous acetone in presence of anhydrous potassium carbonate forming its ethyl ester. The crude ester was treated with potassium carbonate in DMF under reflux Synthesis, SAR, Molecular Docking and Antituberculosis Study of 3-Methyl-1-Benzofuran-2-Carbohydrazide
3-Methyl-1-Benzofuran-2-Carbohydrazide shows potential as an antituberculosis drug due to its synthesis, SAR, Molecular Docking, and pharmacokinetic studies.
Full text analysis coming soon...