Paper
SYNTHESIS AND MOLECULAR DOCKING STUDIES OF DIETHYL 2-{[3-(2,4,6- TRIMETHYL BENZYL)-1-PHENYLSULFONYL-1H-INDOL-2- YL]METHYL-IDENE}PROPANEDIOATE AGAINST HYPERTENSIVE PROTEIN AS A POTENTIAL TARGET
Published Sep 1, 2013 · B. Saravanan, Akhilesh Upgade, Anusha Bhaskar Manivannan
Asian Journal of Pharmaceutical and Clinical Research
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Abstract
High blood pressure and cardiac failure is the most common ailments which directly affect the health economy of the country. An estimated 68 million people are suffering from hypertension which leads to cardiac arrest and kidney malfunction. This pilot study is designed in which Diethyl 2-{[3-(2,4,6-trimethylbenzyl)-1-phenylsulfonyl-1H-indol-2-yl]methylidene}propanedioate an indole based compound was synthesized in our laboratory, and was studied for antihypertensive activity using a renin protein which plays a major role in high blood pressure. Docking studies were performed on structure activity relationship to show the synthesized compound having a renin inhibitory activity which has the promising results. Keywords: renin, high BP, Diethyl 2-{[3-(2, 4, 6-trimethylbenzyl)-1-phenylsulfonyl-1H-indol-2-yl]methylidene}propanedioate,molecular docking, hypertension, targeted drug delivery
In Vitro StudyDiethyl 2-[3-(2,4,6-trimethylbenzyl)-1-phenylsulfonyl-1H-indol-2-yl]methylidene-propanedioate shows promising antihypertensive activity by inhibiting renin
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