Synthesis and neurotropic activity of new 3-(arylmethyl)aminopyridine-2(1H)-one

doi:10.1007/s11696-021-01696-7

Paper

Synthesis and neurotropic activity of new 3-(arylmethyl)aminopyridine-2(1H)-one

Published May 19, 2021 · I. Palamarchuk, Z. Shulgau, M. Kharitonova

Chemical Papers

Q2 SJR score

8

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0

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Abstract

The reaction of 3-amino-6-methyl-4-phenylpyridine-2(1H)-one with aromatic aldehydes resulted in the corresponding Schiff bases, which reduction with sodium borohydride led to the formation of 3-(arylmethylamino)-6-methyl-4-phenylpyridine-2(1H)-ones. The structure of all prepared compounds was proved by 1H and 13C NMR spectroscopy. The initial evaluation of the synthesized compounds in vivo was carried out for a tranquilizing (anxiolytic) activity by «light–dark box test» and antidepressant activity by Porsolt’s «behavioral despair test». Several derivatives of 3-(arylmethylamino)-6-methyl-4-phenylpyridine-2(1H)-one with higher potential neurotropic activity than that of the comparator drugs (Mexidol and Amitriptyline) were detected.

Study Snapshot

New 3-(arylmethyl)aminopyridine-2(1H)-one derivatives show higher potential neurotropic activity than drugs Mexidol and Amitriptyline, with potential applications in treating anxiety and depression.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and neurotropic activity of new 3-(arylmethyl)aminopyridine-2(1H)-one

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