Paper
Synthesis of novel 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones as anticonvulsant agents.
Published Jun 1, 2008 · Zhongyuan Piao, Liping Guan, Li‐Ming Zhao
European journal of medicinal chemistry
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22
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Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal StudyStudy Snapshot
7-(4-fluorobenzylamino)-2H-1,4-benzoxazin-3(4H)-one 4b shows potent anticonvulsant activity and low neurotoxicity, with potential applications in treating epilepsy.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Synthesis, antimicrobial activity and QSARs of new benzoxazine-3-ones.
New benzoxazine-3-ones show broad antimicrobial activity against various bacteria and yeast species, with MIC values ranging from 6.25-100 micro g/ml.
2006·60citations·Sabiha Alper-Hayta et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
QSAR study of antiplatelet agents.
The multilinear model provides satisfactory stability and predictive ability for antiplatelet activity, while the nonlinear approach shows slightly superior predictive ability.
2006·16citations·A. Katritzky et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Quantitative structure activity relationship of benzoxazinone derivatives as neuropeptide Y Y5 receptor antagonists.
The study developed a quantitative structure activity relationship (QSAR) for 30 benzoxazinone derivatives acting as neuropeptide Y Y5 receptor antagonists, using genetic algorithm and multiple linear regression.
2006·12citations·S. Deswal et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists.
The novel 3,4-dihydro-2H-benzo[1,4]oxazin-8-yloxyacetic acid derivatives show potential as dual-acting agents that block the TXA2 receptor and activate the PGI2 receptor, offering a promising treatment for anti-thrombotic and cardiovascular fields
2006·21citations·M. Ohno et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Anti-Candida albicans properties of novel benzoxazine analogues.
1,4-benzoxazine analogues show significant antifungal activity and can cure mice systemically infected with Candida albicans, improving immune response against the infection.
2002·54citations·R. Fringuelli et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae).
The methanolic extract of Cyperus articulatus rhizomes possesses anticonvulsant properties in mice, potentially explaining its traditional use as a medicine for epilepsy in Africa and Latin America.
2001·139citations·E. Bum et al.·Journal of ethnopharmacology
Journal of ethnopharmacology
Vigabatrin as an anticonvulsant against pentylenetetrazol seizures.
Gamma vinyl GABA effectively reduces seizure intensity in pentylenetetrazol seizures, but at higher doses, it is less effective and prolongs seizure latency.
1993·32citations·U. Sayin et al.·Pharmacological research
Pharmacological research
Chemical models of epilepsy with some reference to their applicability in the development of anticonvulsants
Chemical models of epilepsy can help identify and characterize anticonvulsants, with some having predictive value for clinical efficacy and contributing to a better understanding of epileptogenesis mechanisms.
1992·172citations·P. Deyn et al.·Epilepsy Research
Epilepsy Research
Synthesis and biological activities of new 2-substituted 1,4-benzoxazine derivatives.
New 1,4-benzoxazine derivatives show potent antihypertensive effects in rats, with calmodulin antagonistic activity comparable to trifluoperazine.
1991·52citations·M. Kajino et al.·Chemical & pharmaceutical bulletin
Chemical & pharmaceutical bulletin
Citations
Synthetic approach to new 2H-benzo[b] [1,4] oxazin-3-one derivatives containing 1,2,3-triazole by click chemistry
Novel 1,2,3-triazoles linked to benzoxazin-3-one moiety were synthesized using double copper-catalyzed azide-alkyne click chemistry, offering potential biological applications.
2024·0citations·Addichi Darifa et al.·Tetrahedron
Tetrahedron
Design, synthesis and antifungal activity of novel 1,4-benzoxazin-3-one derivatives containing an acylhydrazone moiety
Novel 1,4-benzoxazin-3-one derivatives with an acylhydrazone moiety show moderate to good antifungal activities against various fungi, including Gibberella zeae, Pellicularia sasakii, Phytophthora infestans, and Cap
2023·1citation·Chenghao Tang et al.·Frontiers in Chemistry
Frontiers in Chemistry
Synthesis, antiproliferative evaluation and in silico studies of a novel steroidal spiro morpholinone
The novel steroidal spiro morpholinone derivative shows potent antiproliferative activity against estrogen-dependent and independent solid tumor cell lines, with potential for use in aromatase inhibitor-based cancer treatments.
2023·2citations·Luis A. Cobos-Ontiveros et al.·Steroids
Steroids
Electrochemical synthesis of new sulfone and sulfonamide derivatives. A green method based on the electrolysis of 2-amino-5-nitrophenol
This study successfully developed a green, efficient method for the synthesis of diarylsulfone derivatives using 2-amino-5-nitrophenol under environmentally friendly conditions.
2021·2citations·A. Daneshyar et al.·Electrochimica Acta
Electrochimica Acta
Synthesis and evaluatation of N-substituted (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)-2-thioxothiazolidin-4-one derivatives and 5-substituted-thioxothiazolidindione derivatives as potent anticonvulsant agents.
Stiripentol, a promising lead compound, shows remarkable anticonvulsant activities and NaV1.1 channel inhibition as its mechanism of action.
2019·0citations·Shiyang Dong et al.·CNS & neurological disorders drug targets
CNS & neurological disorders drug targets
Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties
Novel paeonol derivatives containing 1,4-benzoxazinone and 1,2,3-triazole moieties show significant inhibitory activity against human non-small cell lung cancer NCI-H1299 and cervical carcinoma HeLa cells.
2019·5citations·Tingting Yang et al.·Journal of Chemical Research
Journal of Chemical Research
Docking, Synthesis, Antifungal and Cytotoxic Activities of Some Novel Substituted 4H-Benzoxazin-3-one
Novel 4H-benzoxazin-3-one derivatives show significant antifungal and cytotoxic activities against various fungi and cancer cells.
2019·6citations·L. Zamani et al.·Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds
SYNTHESIS AND EVALUATION OF SOME NEWER QUINAZOLINONYL SUBSTITUTED BENZOXAZEPINYL / BENZOTHIAZEPINYL INDOLES AS POTENT ANTICONVULSANT AGENTS
Coumpund 44, a new series of quinazolin-4-substituted benzoxazepine/benzothiazepine indoles, shows potential as a potent anticonvulsant agent, more potent than standard phenytoin sodium.
2019·1citation·Archana.·INDIAN DRUGS
INDIAN DRUGS
Design, synthesis, biological evaluation, homology modeling and docking studies of (E)-3-(benzo[d][1,3]dioxol-5-ylmethylene) pyrrolidin-2-one derivatives as potent anticonvulsant agents.
Compound 6d shows promising anticonvulsant activity and inhibits Na v 1.1 channels, offering potential for designing small-molecule drugs to treat epilepsy.
2018·6citations·Tiantian Wang et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters