Synthesis of novel 3-amino-2-(4-chloro-2-mercaptobenzenesulfonyl)-guanidine derivatives as potential antitumor agents.

doi:10.1016/J.EJMECH.2007.01.020

Paper

DOI: 10.1016/J.EJMECH.2007.01.020

Synthesis of novel 3-amino-2-(4-chloro-2-mercaptobenzenesulfonyl)-guanidine derivatives as potential antitumor agents.

Published Sep 1, 2007 · Z. Brzozowski, F. Sa̧czewski, J. Sławiński

European journal of medicinal chemistry

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Novel 3-amino-2-(4-chloro-2-mercaptobenzenesulfonyl)-guanidine derivatives show promising antitumor activity against various human tumor cell lines, with selectivity for leukemia RPMI-8226 cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Full text analysis coming soon...

References

DOI: 10.1016/J.EJMECH.2006.05.008

Synthesis and in vitro antitumor activity of novel series 2-benzylthio-4-chlorobenzenesulfonamide derivatives.

Novel 2-benzylthio-4-chlorobenzenesulfonamide derivatives show promising in vitro antitumor activity and selectivity against non-small cell lung cancer and melanoma cell lines.

2006·21citations·J. Sławiński et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1021/JM0602716

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.

PBTDs show high apoptotic activity in chronic myelogenous leukemia cells, making them a promising new class of treatments for imatinib-resistant CML.

2006·46citations·R. Silvestri et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/J.BMCL.2006.06.064

Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.

Substituted aromatic sulfonamides show potential as hypoxia-activatable drugs for inhibiting carbonic anhydrase enzymes in human and tumor cells.

2006·49citations·F. Sa̧czewski et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1021/JM060531J

Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.

Hypoxia-activatable carbonic anhydrase inhibitors targeting tumor-associated isoforms show potential as a promising treatment for cancer.

2006·98citations·G. De Simone et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/J.CTRV.2006.04.011

Future opportunities in preventing cisplatin induced ototoxicity.

Otoprotectors show promise in preventing cisplatin-induced ototoxicity, potentially increasing the effectiveness of cisplatin therapy and improving the quality of life for patients.

2006·100citations·J. H. van den Berg et al.·Cancer treatment reviews

Cancer treatment reviews

Citations

DOI: 10.1007/s40199-019-00272-5

Design, synthesis, and biological evaluation of polyphenols with 4,6-diphenylpyrimidin-2-amine derivatives for inhibition of Aurora kinase A

Derivative 12 is an AURKA inhibitor that reduces clonogenicity, arrests the cell cycle at the G2/M phase, and induces caspase-mediated apoptosis in HCT116 human colon cancer cells.

2019·7citations·Young Han Lee et al.·DARU Journal of Pharmaceutical Sciences

DARU Journal of Pharmaceutical Sciences

DOI: 10.1515/ZNB-2018-0102

Syntheses and crystal structures of guanidine hydrochlorides with two Schiff base functions as efficient colorimetric and selective sensors for fluoride

Guanidine hydrochlorides with two Schiff base functions serve as efficient colorimetric and selective sensors for fluoride, showing selective color changes from colorless to yellow or orange, red-shifted in ultraviolet/visible absorption spectra.

2018·6citations·Bei Wang et al.·Zeitschrift für Naturforschung B

Zeitschrift für Naturforschung B

DOI: 10.1016/j.cbi.2017.12.009

Aminoguanidine hydrazones (AGH's) as modulators of norfloxacin resistance in Staphylococcus aureus that overexpress NorA efflux pump.

Aminoguanidine hydrazones (AGH) show potential as potent inhibitors of NorA efflux pump, potentially improving the effectiveness of antibiotics against Staphylococcus aureus.

2018·27citations·Natalina Dantas et al.·Chemico-biological interactions

Chemico-biological interactions

DOI: 10.1016/j.ejmech.2017.06.059

Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents - Synthesis, molecular structure, QSAR studies and metabolic stability.

Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives show potent anticancer properties and good metabolic stability, with potential for further development of similar compounds with better biological properties.

2017·17citations·Aneta Pogorzelska et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1002/JHET.1562

Synthesis of Novel Series of 6-Chloro-1,1-dioxo-1,4,2-benzodithiazine Derivatives with Potential Biological Activity

This study synthesized a series of novel 6-chloro-1,1-dioxo-1,4,2-benzodithiazine derivatives with potential biological activity, offering a new approach for synthesis of organic compounds with potential biological activity.

2013·1citation·Z. Brzozowski et al.·Journal of Heterocyclic Chemistry

Journal of Heterocyclic Chemistry