Synthesis of Novel Heterocyclic Compounds with Expected Antibacterial Activities from 4-(4-Bromophenyl)-4-oxobut-2-enoic Acid

doi:10.1002/JHET.2182

Paper

Synthesis of Novel Heterocyclic Compounds with Expected Antibacterial Activities from 4-(4-Bromophenyl)-4-oxobut-2-enoic Acid

Published May 1, 2015 · M. El-hashash, A. Soliman, H. Bakeer

Journal of Heterocyclic Chemistry

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Abstract

This research describes the utility of 4-(4-bromophenyl)-4-oxobut-2-enoic acid as a key starting material for preparation of a novel series of aroylacrylic acids, pyridazinones, and furanones derivatives. These heterocyclic compounds were synthesized by reaction of 4-(4-bromophenyl)-4-oxobut-2-enoic acid with benzimidazole, ethyl glycinate hydrochloride, anthranilic acid and o-phenylenediamine under Aza–Michael addition conditions. Every Aza–Michael adduct was allowed to react with haydrazine hydrate and acetic anhydride to form pyridazinones and furanones derivatives, respectively. In further step, some pyridazinones were allowed to react with ethyl acetoacetate, acetyl acetone, acetyl chloride, and aromatic aldehydes to form novel heterocylces. Finally, studying antibacterial activities of these compounds was performed.

Study Snapshot

4-(4-bromophenyl)-4-oxobut-2-enoic acid is a key starting material for synthesizing novel heterocyclic compounds with potential antibacterial activities.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis of Novel Heterocyclic Compounds with Expected Antibacterial Activities from 4-(4-Bromophenyl)-4-oxobut-2-enoic Acid

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