Synthesis and Pharmacological Use of 10H-Phenothiazines, Their Sulfones, and Ribofuranosides

doi:10.1080/10426501003671452

Paper

Synthesis and Pharmacological Use of 10H-Phenothiazines, Their Sulfones, and Ribofuranosides

Published Nov 19, 2010 · N. Gautam, N. Ajmera, Shikha Gupta

Phosphorus, Sulfur, and Silicon and the Related Elements

UNKNOWN SJR score

1

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

This article describes the synthesis of 10H-phenothiazines from 2-aminobenzenethiol and o-halonitrobenzenes via Smiles rearrangement. Upon refluxing with hydrogen peroxide in glacial acetic acid, these phenothiazines yield the corresponding 10H-phenothiazine-5,5-dioxides. The phenothiazines have also been used as base to prepare ribofuranosides by the reaction with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate. All the synthesized compounds have been characterized by spectral and elemental analysis and have been examined for antioxidant and antimicrobial activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Study Snapshot

10H-phenothiazines, their sulfones, and ribofuranosides show potential as pharmaceutical agents due to their antioxidant and antimicrobial properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and Pharmacological Use of 10H-Phenothiazines, Their Sulfones, and Ribofuranosides

References

Citations