Synthesis of Photoreactive 2‐Phenethylamine Derivatives – Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling

doi:10.1002/EJOC.201201657

Paper

Synthesis of Photoreactive 2‐Phenethylamine Derivatives – Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling

Published Apr 1, 2013 · Yuta Murai, K. Masuda, Yuichi Ogasawara

European Journal of Organic Chemistry

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9

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Abstract

2-Phenylethylamine is well known as a substructure of many biologically active compounds, and the synthesis of its photoreactive derivatives to allow the analysis of biological functions is reported. This allowed us to synthesise ligands for adenosine receptors, which have many functional roles in biology and have been extensively studied for their many roles in maintaining homeostasis. Adenosine is one of the most common biochemical compounds, but photoaffinity labeling has not yet been used to study adenosine receptors. Synthetic methods for producing photoreactive adenosine derivatives that can be used with adenosine receptors were established for the photophores phenyl azide and benzophenone. The effect of the introduction of the photoreactive components was determined using an adenosine receptor assay.

Study Snapshot

Photoreactive 2phenethylamine derivatives enable functional analysis of adenosine receptors using photoaffinity labeling, enabling new insights into biological functions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis of Photoreactive 2‐Phenethylamine Derivatives – Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling

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