Paper
Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs.
Published 1984 · E. D. Clercq, E. Clercq, R. Walker
Pharmacology & therapeutics
Q1 SJR score
91
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
5-Vinylpyrimidine nucleoside analogs show potential as highly potent and selective inhibitors of herpes simplex virus type 1 and varicella-zoster virus, with potential for clinical use against these infections.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Full text analysis coming soon...
References
Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella-zoster virus eye infections.
Bromovinyldeoxyuridine (BVDU) is effective in treating herpes simplex virus and varicella-zoster virus eye infections, with potential for use in combination with oral BVDU for prompt healing.
1984·39citations·P. Maudgal et al.·Antiviral research
Antiviral research
Investigation of antiviral activity of 1-beta-D-arabinofuranosylthymine (ara-T) and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-ara-U) in monkeys infected with simian varicella virus.
Both ara-T and BV-ara-U effectively prevent simian varicella virus infection in African green monkeys, but ara-T may cause neurotoxicity.
1984·29citations·K. Soike et al.·Antiviral research
Antiviral research
Influence of various experimental conditions on the inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on varicella-zoster virus replication in cell culture.
BVDU effectively inhibits varicella-zoster virus replication in human embryonal fibroblast cultures, with a 50% inhibitory dose of 0.016 micrograms/ml, and its effectiveness increases with increasing multiplicity of infection.
1984·10citations·M. Baba et al.·The Tohoku journal of experimental medicine
The Tohoku journal of experimental medicine
Inhibition of human and woodchuck hepatitis virus DNA polymerase by the triphosphates of acyclovir, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and E-5-(2-bromovinyl)-2'-deoxyuridine.
FIACTP is the most potent inhibitor of human and woodchuck hepatitis virus DNA polymerase, while ACVTP is the least effective inhibitor.
1984·58citations·O. Hantz et al.·Antiviral research
Antiviral research
Differential antiherpes activity of the (E)-and (Z)-isomers of 5-(2-fluorovinyl)-2'-deoxyuridine (FVUdR).
(E)-BrVUdR has greater antiherpes activity than (E)-FVUdR and (E)-EOVUdR, while (Z)-FVUdR and (Z)-COOH-FVUdR are inactive against HSV-1 and H
1984·8citations·J. Reefschläger et al.·Acta virologica
Acta virologica
Citations
5-Ethynyl-2′-deoxycytidine and 5-ethynyl-2′-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses
EdU is the preferable nucleoside analogue for short pulse-labeling experiments, as it enables increased recovery and sensitivity for downstream applications.
2020·12citations·Salomé Manska et al.·The Journal of Biological Chemistry
The Journal of Biological Chemistry
Theoretical investigation of 5-(2-acetoxyethyl)-6-methylpyrimidin-2,4-dione: conformational study, NBO and NLO analysis, molecular structure and NMR spectra.
The study reveals that charge transfer occurs within 5-(2-acetoxyethyl)-6-methylpyrimidin-2,4-dione, with the most stable form being the most studied conformation.
2013·65citations·Hacer Pir et al.·Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Laser treatment of recurrent herpes labialis: a literature review
Laser phototherapy can effectively decrease pain and recurrence intervals without causing side effects, while photodynamic therapy may help reduce viral titer in the vesicle phase.
2013·55citations·C. Eduardo et al.·Lasers in Medical Science
Lasers in Medical Science
Synthesis, X-ray crystal structure study and antitumoral evaluations of 5,6-disubstituted pyrimidine derivatives.
5,6-disubstituted pyrimidine derivatives show promising antitumoral effects, with 2,4-dichloro-5-chloroethylpyrimidine showing marked activity against human colon carcinoma.
2010·19citations·Tatjana Gazivoda Kraljević et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Oral and perioral herpes simplex virus type 1 (HSV-1) infection: review of its management.
Systemic antiviral therapy is effective for primary herpetic gingivostomatitis, topical therapy is effective for herpes labialis, and prophylactic oral aciclovir may reduce recurrent attacks in immunocompromised patients.
2006·151citations·P. Arduino et al.·Oral diseases
Oral diseases
[New antivirals for herpesviruses].
New antivirals targeting different viral enzymes show promise in combating drug-resistant herpesviruses.
2005·2citations·Y. Eizuru·Uirusu
Uirusu
(E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU)
BVDU is a highly potent and selective inhibitor of herpes simplex virus type 1 and varicella-zoster virus infections, offering potential in a combined gene therapy/chemotherapy approach for cancer.
2005·35citations·E. Clercq·Medicinal Research Reviews
Medicinal Research Reviews
Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster.
BVDU is an effective and convenient treatment for herpes zoster, with high selectivity and activity against varicella-zoster virus and herpes simplex virus type 1, but should not be used with 5-fluorouracil therapy.
2004·85citations·E. Clercq·Biochemical Pharmacology
Biochemical Pharmacology