Synthesis and spectroscopic characterization of dimethylgermanium derivatives of dipeptides, crystal structure of dimethylgermanium glycylglycinate and in vivo effects of dimethylgermanium glycylglycinate against murine leukemia P388

doi:10.1002/AOC.590030210

Paper

Synthesis and spectroscopic characterization of dimethylgermanium derivatives of dipeptides, crystal structure of dimethylgermanium glycylglycinate and in vivo effects of dimethylgermanium glycylglycinate against murine leukemia P388

Published 1989 · Michael Vornefeld, F. Huber, H. Preut

Applied Organometallic Chemistry

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9

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Abstract

Dimethylgermanium derivatives of dipeptides, Me2GeAA (H2AA = H2glygly, H2glyala, H2glyval, H2glyleu, H2glymet) have been obtained by the reaction of Me2GeBr2 with H2AA in the presence of triethylamine. The crystal structure of Me2Geglygly has been determined by single-crystal X-ray diffraction. The dipeptide is tridentately coordinated to germanium, which has a distorted trigonal bipyramidal environment. From infrared and Raman data, analogous molecular structures are inferred for the other dimethylgermanium derivatives of dipeptides. 1H NMR measurements show that Me2Geglygly is completely hydrolyzed in aqueous solution to give H2glygly and (Me2Geo)x. In vivo tests with Me2Geglygly showed no toxic or antitumor activity against murine leukemia P388.

In Vitro Study

Study Snapshot

Dimethylgermanium derivatives of dipeptides show no toxic or antitumor activity against murine leukemia P388.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and spectroscopic characterization of dimethylgermanium derivatives of dipeptides, crystal structure of dimethylgermanium glycylglycinate and in vivo effects of dimethylgermanium glycylglycinate against murine leukemia P388

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