Paper
Synthesis, Transformation of 3-[(4-Arylthiazol-2-yl)(p-tolyl)amino]propanoic Acids, Bis(thiazol-5-yl)phenyl-, Bis(thiazol-5-yl)methane Derivatives, and Their Antimicrobial Activity
Published 2018 · V. Mickevičius, Birutė Grybaitė, R. Vaickelionienė
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Abstract
Bis(thiazol-5-yl)phenyland bis(thiazol-5-yl)methanes were synthesized by the reaction of 2,4-disubstituted thiazoles with aromatic aldehydes or formaldehyde. In addition, modification of the carboxyl group of the molecule was carried out. The reactions afforded compounds bearing various heterocyclic fragments. All the synthesized compounds were tested for their effect on Escherichia coli, Staphylococcus aureus and Mycobacterium luteum bacteria and Aspergillus niger and Candida tenuis fungi strains. Some of them exhibited antibacterial activity against test-culture Mycobacterium luteum. INTRODUCTION The treatment of infectious diseases remains a challenging task because over time bacteria have become increasingly resistant to antibiotics. The wide use of antibiotics led to the mutation of microorganisms. They have acquired the ability to prevent the normal function of antibiotics. Mutated bacteria produce a novel mechanism to defeat the action of many antibiotics. This has induced new diseases and at the same time has become a reason for a very complicated problem. Hence, in spite of a large number of antibiotics applied for medical uses the emerging resistance to antibiotic substances has created a real need for novel classes of antimicrobial agents. Therefore, the design of new and effective molecules as antimicrobial agents is a target task nowadays. 86 HETEROCYCLES, Vol. 96, No. 1, 2018
In Vitro StudySynthesis and antibacterial activity of bis(thiazol-5-yl)phenyland bis(thiazol-5-yl)methane derivatives show potential as novel antimicrobial agents against antibiotic-resistant bacteria and fungi.
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