Paper
Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives
Published May 24, 2007 · Haiwen Zhang, V. Solomon, Changkun Hu
Biomedicine & Pharmacotherapy
Q1 SJR score
43
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0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
4-aminoquinoline derivatives show potential as a new class of anticancer agents, with N ′-(7-chloro-quinolin-4-yl)-N,N -dimethyl-ethane-1,2-diamine showing the most potent effects on MDA-
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Full text analysis coming soon...
References
Recent advances in antimalarial drug development
Recent advances in antimalarial drug development show promise in addressing the need for new classes of agents and re-examining existing drugs for effectiveness against resistant strains.
2007·105citations·S. Vangapandu et al.·Medicinal Research Reviews
Medicinal Research Reviews
Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme
Chloroquine, in addition to surgery, radiotherapy, and chemotherapy, may prolong survival in patients with glioblastoma multiforme by preventing treatment resistance.
2006·475citations·J. Sotelo et al.·Annals of Internal Medicine
Annals of Internal Medicine
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.
4-aminoquinolines (4AQ) show potential as effective antimalarial drugs, with promising new lead compounds under development and potential for use against chloroquine-resistant Plasmodium falciparum.
2006·103citations·P. O’Neill et al.·Current topics in medicinal chemistry
Current topics in medicinal chemistry
Chloroquine-Mediated Radiosensitization is due to the Destabilization of the Lysosomal Membrane and Subsequent Induction of Cell Death by Necrosis
Chloroquine-mediated radiosensitization is due to destabilization of lysosomal membranes and increased cell death by necrosis, rather than apoptosis alone.
2005·72citations·Helen Zhao et al.
Anticancer therapeutics: "Addictive" targets, multi-targeted drugs, new drug combinations.
New anticancer drugs focus on receptor tyrosine kinase inhibitors, multi-targeted drugs, and new drug combinations, with potential for cures and long-term survival in intractable cancers.
2005·116citations·H. Broxterman et al.·Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Design and synthesis of new antimalarial agents from 4-aminoquinoline.
New 4-aminoquinoline derivatives show potential as new antimalarial agents by targeting heme polymerization and forming strong complexes with hematin.
2005·65citations·V. Solomon et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
Chloroquine effectively inhibits the replication of SARS-CoV in vitro, making it a potential treatment for prevention and treatment of SARS-CoV infections.
2004·617citations·E. Keyaerts et al.·Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications
New cancer therapeutics: target-specific in, cytotoxics out?
Target-specific cancer therapeutics show promise in maximizing therapeutic benefit while minimizing toxicity to normal cells, but more research is needed for broad clinical use.
2004·23citations·H. Broxterman et al.·Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Effects of chloroquine on viral infections: an old drug against today's diseases
Chloroquine shows potential antiviral effects against various viral infections, including HIV, and may be resurrected for clinical management of viral diseases like AIDS and severe acute respiratory syndrome.
2003·1196citations·Adrea Savarino et al.·The Lancet. Infectious Diseases
The Lancet. Infectious Diseases
Citations
4-Aminoquinoline derivatives as potent inhibitors of pancreatic cancer: Synthesis, evaluation and docking studies.
Compound 3g shows potential as an effective pancreatic cancer treatment by inducing dose-dependent cell cycle arrest and targeting cyclooxygenase-2.
2024·1citation·Nagaraju Chirra et al.·Journal of Molecular Structure
Journal of Molecular Structure
Novel 4-aminoquinoline analogs targeting the HIF-1α signaling pathway.
Compound 3s, a 4-aminoquinoline analog, shows promising anticancer activity by targeting the HIF-1 signaling pathway and exhibiting exceptional antiproliferative effects in cancer cells.
2023·1citation·Yu-Chieh Wu et al.·Future medicinal chemistry
Future medicinal chemistry
Synthesis and antimalarial activity of 7-chloroquinoline-tethered sulfonamides and their [1,2,3]-triazole hybrids.
7-chloroquinoline-sulfonamide hybrids show noncytotoxicity and significant antimalarial activity against Plasmodium falciparum, offering potential for next-generation antimalarials.
2022·5citations·Neha Batra et al.·Future medicinal chemistry
Future medicinal chemistry
Synthesis, in silico docking studies, and antiplasmodial activity of hybrid molecules bearing 7‐substituted 4‐aminoquinoline moiety and cinnamic acid derivatives
The synthesized hybrid compounds of 7-substituted 4aminoquinoline and cinnamic acid show moderate antiplasmodial activity against Pf3D7 chloroquine-sensitive strains, with compounds C14 and C17 showing the best inhibitor candidates.
2022·5citations·Fostino R B Bokosi et al.·Chemical Biology & Drug Design
Chemical Biology & Drug Design
Design, synthesis, and biological evaluation of novel morpholinated isatin–quinoline hybrids as potent anti‐breast cancer agents
AS-4 shows potential as a potent and safer anti-breast cancer agent, selectively targeting hormone-positive MCF-7 cells and blocking estrogen receptor alpha.
2021·20citations·Atamjit Singh et al.·Archiv der Pharmazie
Archiv der Pharmazie
Design, Synthesis and Biological Evaluation of Morpholinated Isatin-Quinoline Hybrids as Potential Anti-Breast Cancer Agents.
AS-4 shows potential as a potent and safer anti-breast cancer agent by selectively inhibiting hormone-positive MCF-7 cells and blocking estrogen receptor alpha.
2021·1citation·Atamjit Singh et al.
Heterocyclic N-oxides as small-molecule fluorogenic scaffolds: rational design and applications of their "on-off" fluorescence.
Heterocyclic N-oxidation can rapidly expand and optimize the existing fluorophore library, enabling new probe designs for chemical analysis and biological imaging.
2020·9citations·Zhao Ma et al.·Analytical chemistry
Analytical chemistry
Examination of novel 4-aminoquinoline derivatives designed and synthesized by a hybrid pharmacophore approach to enhance their anticancer activities
Compound 13 shows potential as a promising anticancer agent, effective on a wide range of cancers and potentially less toxic to normal cells, with potential for enhanced potency when combined with bortezomib or monastrol.
2019·23citations·V. Solomon et al.·Scientific Reports
Scientific Reports
Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach
Compound 23 shows significant anti-breast cancer activity, with 7-11 fold higher antigrowth/cell-killing activity compared to non-cancer cells, making it a promising lead for effective and safe anticancer drugs.
2019·26citations·R. Viswas et al.·Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry