Paper
Tamsulosin
Published 2002 · C. Dunn, A. Matheson, D. Faulds
Drugs & Aging
120
Citations
5
Influential Citations
Abstract
1. The present study was designed to assess the displacement potencies of tamsulosin to 3 H-prazosin bindings in two α 1 -adrenoceptor (AR) subtypes (α 1H and α 1L ) in bovine prostate, rat heart and brain compared with those of amosulalol, labetalol , ketanserin , clonidine and propranolol . 2. The p K i values of tamsulosin to α 1H and α 1L subtypes in bovine prostate were 9.13 and 8.99 and these values were almost the same as those of prazosin . On the other hand, low p K i binding values of amosulalol, labetalol, ketanserin, clonidine and propranolol to these subtypes were observed. 3. Low p K i values of tamsulosin to α 2 - and β-ARs and muscarinic and 5HT 2 receptors in the rat brain were observed. 4. These results suggest that tamsulosin has high affinities to α 1L -AR subtypes in bovine prostate and rat hearts as well as α 1H -AR subtypes, implying an inhibitory effect of this drug on the contraction of the prostate.
Literature Review
Highly CitedTamsulosin 0.4 mg once daily effectively treats lower urinary tract symptoms in patients with benign prostatic hyperplasia, offering advantages over other alpha(1)-adrenoceptor antagonists in single-daily dosing and low hypotensive effects.
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