K. Rao, John Juchum
Apr 1, 1998
Abstract Large-scale processing of the chloroform extract of the bark of Taxus brevifolia by reversed phase column chromatography on C-18 bonded silica using acetonitrile/water mixtures, gave a taxane-rich fraction which emerged just after the elution of paclitaxel. Re-chromatography of this fraction yielded 15 taxane constituents, many of which were obtained in crystalline from, and variously belonging to the 11(15 → 1)-abeotaxane group, taxinine J group, brevifoliol group and those with an oxygenation pattern at the 14 position. Five of these were new and several others were isolated for the first time from this source.