Abstract Tetrakis(trimethylsilyl) ethenylidenebisphosphonate is proposed as a substrate in the preparations of N-substituted 2-aminoethylidene-1,1-bisphosphonic acids. The method provides an extremely mild protocol for the synthesis of these compounds and is compatible with a wide range of functional groups.

This study presents a mild and versatile method for the synthesis of N-substituted 2-aminoethylidene-1,1-bisphosphonic acids using tetrakis(trimethylsilyl) ethenylidenebisphosphonate.

Phosphorus, Sulfur, and Silicon and the Related Elements

Tetrakis(trimethylsilyl) Ethenylidenebisphosphonate: A Mild and Useful Reagent for the Synthesis of Substituted 2-Aminoethylidene-1,1-bisphosphonic Acids

Paper

Tetrakis(trimethylsilyl) Ethenylidenebisphosphonate: A Mild and Useful Reagent for the Synthesis of Substituted 2-Aminoethylidene-1,1-bisphosphonic Acids

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