Paper
The addition of milk to coffee decreases the urinary excretion of chlorogenic acids and metabolites in humans when compared to plain coffee
Published Apr 1, 2010 · Giselle Silva Duarte, A. Farah
The FASEB Journal
0
Citations
0
Influential Citations
Abstract
In vitro digestion studies have reported a potential negative effect of milk addition to coffee and tea on their phenolic compounds’ absorption by humans. This study evaluated the effect of milk addition on the urinary excretion of chlorogenic acids (CGA) and metabolites in 5 healthy adults after the consumption of a regular coffee brew containing 561μmol of CGA. On separate days, each volunteer ingested 4g of instant coffee diluted in either water or whole milk. Urine samples were collected at baseline and for 24h after the beverage consumption. CGA and metabolites were determined in urine by HPLC/LC‐MS. Six CGA (3 caffeoylquinic and 3 dicaffeoylquinic acids) and 15 metabolites (caffeic, vanillic, ferulic, isoferulic, p‐coumaric, gallic, 4‐hydroxybenzoic, dihydrocaffeic, syringic, sinapic, 2,4‐dihidroxybenzoic, 3,4‐dihidroxyphenilacetic, 3‐(4‐hydroxyphenil) propionic, trans‐ 3‐hydroxycinnamic and benzoic acids) were quantified in the urine samples. The total urinary excretion after coffee‐milk consumption (0.5mmol) was lower (p<0.05) than after coffee‐water consumption (0.8mmol). On average, after coffee consumption, 68% of total hydroxycinnamic acid and quinic acid moieties’ derivatives were recovered in urine, while after coffee‐milk consumption only 40% was recovered. This study indicates that milk addition to coffee negatively affects the bioavailability of CGA in humans.
Non-RCTMilk addition to coffee decreases the urinary excretion of chlorogenic acids and metabolites in humans compared to plain coffee.
Full text analysis coming soon...