Theophylline increases pyridoxal kinase activity independently from vitamin B6 nutritional status.

Paper

Theophylline increases pyridoxal kinase activity independently from vitamin B6 nutritional status.

Published Mar 1, 1993 · Rhena Delport, J. Ubbink, W. Vermaak

Research communications in chemical pathology and pharmacology

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Abstract

Asthmatics treated with theophylline, a potent inhibitor of pyridoxal kinase and therefore a vitamin B6 antagonist, demonstrated a significant correlation (r = 0.71; p < 0.001) between drug plasma levels and erythrocyte pyridoxal kinase activities. A cross-over, placebo controlled study was completed on 15 healthy volunteers to investigate the mechanism by which theophylline induces pyridoxal kinase activity. The subjects were supplemented with vitamin B6 or placebo for two weeks before theophylline therapy was started. Vitamin B6 supplementation resulted in a four-fold increase in circulating pyridoxal 5'-phosphate levels, while placebo had no effect. When theophylline therapy was commenced, erythrocyte pyridoxal kinase activities increased significantly (p < 0.001) irrespective of whether vitamin B6 or placebo was supplemented. It is concluded that a depressed vitamin B6 status is not responsible for higher erythrocyte pyridoxal kinase activities encountered during theophylline therapy, but that the drug is directly responsible for elevated enzyme levels.

RCT

Study Snapshot

Theophylline therapy increases pyridoxal kinase activity independently of vitamin B6 nutritional status, suggesting the drug is directly responsible for elevated enzyme levels.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Theophylline increases pyridoxal kinase activity independently from vitamin B6 nutritional status.

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