Conjugated polymers and oligomers can serve as highly responsive fluorescent reporters for biosensor applications. However, their optical properties in aqueous media are highly dependent upon environmental conditions. The structure of the paracyclophane framework provides a platform for designing optical reporters that show little sensitivity to surfactants, and thus is well-suited for fluorescent assays. The permanent intramolecular delocalization through the paracyclophane core dominates intermolecular perturbations in spontaneously formed aggregates.

Paracyclophane bichromophores offer new fluorescent optical reporters with minimal sensitivity to surfactants, making them suitable for biosensor applications.

Through-space delocalized water-soluble paracyclophane bichromophores: new fluorescent optical reporters.

Key Takeaway: Paracyclophane bichromophores offer new fluorescent optical reporters with minimal sensitivity to surfactants, making them suitable for biosensor applications.