TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects
Published Aug 27, 2020 · J. Busserolles, Ismail Ben Soussia, Laetitia Pouchol
British Journal of Pharmacology
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Influential Citations
Abstract
Opioids are effective painkillers. However, their risk–benefit ratio is dampened by numerous adverse effects and opioid misuse has led to a public health crisis. Safer alternatives are required, but isolating the antinociceptive effect of opioids from their adverse effects is a pharmacological challenge because activation of the μ opioid receptor triggers both the antinociceptive and adverse effects of opioids.
Study Snapshot
Key takeawayTREK1 channel activation offers a potential alternative analgesic strategy without opioid adverse effects, offering a safer alternative to traditional opioids.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.