Duodecim; laaketieteellinen aikakauskirja
Mild migraine attack can be treated with acetaminophen or NSAIDs either alone or combined with metoclopramide. In severe and devastating attacks triptans should be taken immediately, and not afterwards, when first line NSAIDs have proven ineffektive. No significant differences between triptans can be shown in clinical practice, when recommended doses are used. Opioid analgesics should not be used in the treatment of migraine. The recommended drugs for migraine attacks in children are acetaminophen or ibuprophen. Also intranasal sumatriptan can be used. The first line drugs for prophylactic treatment of migraine are non-ISA betablockers or candesartan and amitriptyline.