Paper
Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement fixation.
Published Jul 18, 1969 · Shulman Nr, Barker Lf
Science
207
Citations
1
Influential Citations
Abstract
Complement fixation techniques are described for measuring a virus-like antigen associated with viral hepatitis. Antigen was found in the blood of 98 percent of 130 patients, with the serum form of hepatitis, from whom multiple samples were obtained. Antibodies arising during hepatitis are usually combined with antigen and cause anticomplementary activity in the serum, which is reversible with excess antigen or antibody. Tests for antigen and specific anticomplementary activity can be used diagnostically and to screen blood donors for hepatitis carriers.
Complement fixation techniques can effectively measure virus-like antigen in hepatitis patients and help diagnose and screen blood donors for hepatitis carriers.
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