Vitamin D and Its Potential Benefit for the COVID-19 Pandemic
Published Mar 17, 2021 · N. Charoenngam, A. Shirvani, M. Holick
Endocrine Practice
Q1 SJR score
55
Citations
5
Influential Citations
Abstract
Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Key takeawayVitamin D supplementation may potentially benefit primary prevention or adjunctive treatment of COVID-19 by enhancing immune system function, regulating kidney and lung function, and reducing endothelial dysfunction and thrombosis.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.
A single high dose of vitamin D3 does not significantly affect hospital length of stay in COVID-19 patients, but may increase serum levels of 25-hydroxyvitamin D.
2021·397citations·Igor H. Murai et al.·JAMA
JAMA
Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients
Prehospitalization vitamin D status does not show a relationship with COVID-19 clinical outcomes in hospitalized patients.
2020·42citations·Betsy Szeto et al.·Endocrine Research
Endocrine Research
LL-37 fights SARS-CoV-2: The Vitamin D-Inducible Peptide LL-37 Inhibits Binding of SARS-CoV-2 Spike Protein to its Cellular Receptor Angiotensin Converting Enzyme 2 In Vitro
Vitamin D treatment may reduce COVID-19 severity by up-regulating LL-37, a peptide with antiviral effects that inhibits SARS-CoV-2 Spike protein binding to its receptor hACE2.
2020·25citations·Annika Roth et al.·bioRxiv
bioRxiv
High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study
High-dose cholecalciferol booster therapy is associated with a reduced risk of mortality in COVID-19 patients, regardless of baseline serum 25(OH)D levels.
2020·134citations·S. Ling et al.·Nutrients
Nutrients
COVID-19, Social Determinants Past, Present, and Future, and African Americans’ Health
COVID-19 has disproportionately impacted African Americans due to structural disadvantages and social and economic inequality, highlighting the need for targeted health and economic mitigation policies.
2020·72citations·L. Snowden et al.·Journal of Racial and Ethnic Health Disparities
Journal of Racial and Ethnic Health Disparities
Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis
Vitamin D deficiency is more prevalent in severe COVID-19 cases, increasing hospitalization and mortality rates.
2020·318citations·M. Pereira et al.·Critical Reviews in Food Science and Nutrition
Critical Reviews in Food Science and Nutrition
No significant association between vitamin D and COVID-19. A retrospective study from a northern Italian hospital.
Vitamin D levels were similar in COVID-19 positive and negative patients, suggesting that vitamin D supplementation may help reduce the risk of infection.
2020·25citations·Davide Ferrari et al.·International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
Elevated IL-10 levels may play a pathological role in COVID-19 severity, rather than acting as a negative-feedback mechanism to suppress inflammation.
2020·248citations·Ligong Lu et al.·Trends in Immunology
Trends in Immunology