Paper
Vitamin D Deficiency Presenting as Fatigue.
Published Aug 1, 2016 · Rahul Gupta, J. Mokta, A. Ranjan
The Journal of the Association of Physicians of India
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Abstract
V D deficiency has emerged as a pandemic affecting about 1 billion people and knows no geographical boundaries with males and females of all ages and ethnic background equally affected. Severe vitamin D deficiency (<10ng/ml) may cause severe fatigue and personality changes, depression like syndrome, chronic sleep disorder, intolerance, immune dysfunction and in long termmulti-system disease. Though, a common symptom in clinical setting (prevalence 5-20%), fatigue has reputation as a vague symptom. Most often, it is ignored by patients and health care providers.1 We had 5 patients who presented with fatigue as their only complaint (Table 1). They had marked lack of energy, feeling of weakness and tiredness without apathy, excessive sleep and depressed mood. They did not have any adverse event in their lives. Except for low serum 25 hydroxyvitamin D levels, all other laboratory parameters including thyroid function, serum cortisol, complete hemogram were normal. They also lacked evidence of immunological, rheumatological and infectious diseasesclinically or laboratory. We treated them with oral cholecalciferol 60,000 IU weekly for 8 weeks followed by 60,000 IU monthly. All 5 patients improved completely with supplementation.
Case ReportVitamin D deficiency can cause fatigue and other symptoms, but treatment with oral cholecalciferol can improve all symptoms.
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