Paper
Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training
Published Dec 15, 2014 · Gøran Paulsen, H. Hamarsland, K. Cumming
The Journal of Physiology
130
Citations
13
Influential Citations
Abstract
Although antioxidant supplements are generally believed to give health benefits, recent experiments show that they may adversely affect adaptations to endurance exercise. This study is the first to investigate the effects of high dosages of vitamins C and E on the cellular and physiological adaptations to strength training in humans. Here we report that vitamin C and E supplementation interfered with exercise‐induced signalling in muscle cells after a session of strength training, by reducing the phosphorylation of p70S6 kinase and mitogen‐activated protein kinases p38 and ERK1/2. The vitamin C and E supplement did not significantly blunt muscle hypertrophy during 10 weeks of training; however, some measurements of muscle strength revealed lower increases in the supplemented group than the placebo group. Even though the cellular events are not clearly reflected in physiological and performance measurements, this study implies that redox signalling is important for inducing skeletal muscle adaptations to strength training and that vitamin C and E supplements in high dosages should be avoided by healthy, young individuals engaged in strength training.
Non-RCT
Highly CitedHigh dosages of vitamin C and E supplements interfere with muscle cell signaling after strength training, but do not significantly blunt muscle growth during 10 weeks of training.
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