Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth.

doi:10.1056/NEJMc1812157

Paper

Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth.

Published 2018 · D. Roth, Alison D. Gernand, A. Al Mahmud

The New England journal of medicine

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Abstract

METHODS We conducted a randomized, double-blind, placebo-controlled trial in Bangladesh to assess the effects of weekly prenatal vitamin D supplementation (from 17 to 24 weeks of gestation until birth) and postpartum vitamin D supplementation on the primary outcome of infants’ length-for-age z scores at 1 year according to World Health Organization (WHO) child growth standards. One group received neither prenatal nor postpartum vitamin D (placebo group). Three groups received prenatal supplementation only, in doses of 4200 IU (prenatal 4200 group), 16,800 IU (prenatal 16,800 group), and 28,000 IU (prenatal 28,000 group). The fifth group received prenatal supplementation as well as 26 weeks of postpartum supplementation in the amount of 28,000 IU (prenatal and postpartum 28,000 group).

Study Snapshot

Key takeawayPrenatal and postpartum vitamin D supplementation significantly improves infant growth at 1 year, with the highest dose of 28,000 IU being optimal for both prenatal and postpartum use.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth.

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