Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1mg/kg.

doi:10.1016/j.neulet.2015.09.008

Paper

DOI: 10.1016/j.neulet.2015.09.008

Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1mg/kg.

Published Oct 8, 2015 · D. Zaretsky, M. Zaretskaia, J. Dimicco

Neuroscience Letters

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Yohimbine, a 5-HT1A agonist, can cause hypothermia and reverse hypertension in rats when doses exceed 1mg/kg, indicating its potential use in pharmacological studies.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/j.ejphar.2013.10.003

Identification and characterization of platelet α2-adrenoceptors and imidazoline receptors in rats, rabbits, cats, dogs, cattle, and horses.

Interspecific variations in platelet 2-adrenoceptor and imidazoline receptor expressions may explain different platelet responses to catecholamines and imidazoline -adrenergic agents.

2013·16citations·Y. Hikasa et al.·European journal of pharmacology

European journal of pharmacology

DOI: 10.1016/j.bbr.2012.10.030

Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats

Yohimbine increases ethanol self-administration and reinstates ethanol seeking in both alcohol-preferring and high alcohol drinking rats, with no systematic differences between the two groups.

2013·23citations·M. Bertholomey et al.·Behavioural Brain Research

Behavioural Brain Research

DOI: 10.1016/j.biopsych.2011.06.010

α2 Adrenergic and Imidazoline Receptor Agonists Prevent Cue-Induced Cocaine Seeking

(2) and I(1) receptor agonists effectively prevent cue-induced cocaine relapse, offering potential therapeutic options for treating addictive disorders.

2011·75citations·Rachel J. Smith et al.·Biological Psychiatry

Biological Psychiatry

DOI: 10.1016/j.ejphar.2010.10.090

Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.

Agmatine can enhance morphine and oxycodone analgesia in mice, with involvement of 2 -adrenoceptors, imidazoline receptors, and opioid receptors.

2011·23citations·S. Bhalla et al.·European journal of pharmacology

European journal of pharmacology

DOI: 10.1016/j.physbeh.2010.09.002

The autonomic stress-induced hyperthermia response is not enhanced by several anxiogenic drugs

Anxiogenic drugs can cause decreased body temperature but may not increase autonomic stress response, suggesting both parameters are independent of each other.

2011·15citations·Lotte C. Houtepen et al.·Physiology & Behavior

Physiology & Behavior

DOI: 10.1097/FBP.0b013e3283096848

Behavior selectively elicited by novel stimuli: modulation by the 5-HT1A agonist 8-OHDPAT and antagonist WAY-100635

The serotonergic system plays a role in the response to novel stimuli, with the highest dose of 8-OHDPAT (0.05 mg/kg) inhibiting locomotor activity.

2008·17citations·R. Carey et al.·Behavioural Pharmacology

Behavioural Pharmacology

DOI: 10.1124/jpet.107.126169

3,4-Methylenedioxymethamphetamine- and 8-Hydroxy-2-di-n-propylamino-tetralin-Induced Hypothermia: Role and Location of 5-Hydroxytryptamine 1A Receptors

MDMA and DPAT-induced hypothermia share a common dependence on 5-HT1A receptor activation, but the location of these receptors is different for each drug.

2007·41citations·D. Rusyniak et al.·Journal of Pharmacology and Experimental Therapeutics

Journal of Pharmacology and Experimental Therapeutics

DOI: 10.1016/j.bbr.2006.06.039

Potentiation of cue-induced reinstatement of cocaine-seeking in rats by the anxiogenic drug yohimbine

Exposure to drug-paired cues during a stressful state can greatly potentiate cocaine-seeking in rats, suggesting multiple treatment modalities are needed.

2006·153citations·M. W. Feltenstein et al.·Behavioural Brain Research

Behavioural Brain Research

DOI: 10.1016/j.physbeh.2006.05.014

Role of food type in yohimbine- and pellet-priming-induced reinstatement of food seeking

Yohimbine and pellet priming effectively reinstate food seeking in food-restricted rats, with greater impact on non-sucrose carbohydrate and sucrose-reinforced rats.

2006·47citations·S. Nair et al.·Physiology & Behavior

Physiology & Behavior

Citations

DOI: 10.3390/ijms252312856

Multifaced Nature of Yohimbine—A Promising Therapeutic Potential or a Risk?

Yohimbine shows promising therapeutic potential for treating erectile dysfunction and metabolic disorders, but higher doses may pose toxicological concerns.

2024·0citations·A. Nowacka et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences

DOI: 10.1021/acssynbio.4c00039

Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine.

Yeast-based cell factories can produce bioactive plant-inspired compounds and screen them for potential therapeutic applications against cancer, psychotic disorders, and erectile dysfunction.

2024·2citations·Samuel A. Bradley et al.·ACS synthetic biology

ACS synthetic biology

DOI: 10.1111/jmp.12682

Effects of atipamezole on selected physiologic parameters in cynomolgus macaques (Macaca fascicularis)

Atipamezole administration alters anesthetic parameters in cynomolgus macaques, reversing the effects of 2 agonist anesthetics.

2023·1citation·K. Schwartz et al.·Journal of Medical Primatology

Journal of Medical Primatology

DOI: 10.1016/j.aquaculture.2023.740003

Biochemical compositions and transcriptome analysis reveal dynamic changes of embryonic development and nutrition metabolism in Chinese sturgeon (Acipenser sinensis)

Chinese sturgeon embryonic development involves continuous energy consumption, with specific energy substrates at different stages, highlighting the importance of high-quality egg production for captive breeding success.

2023·3citations·Meng Zhou et al.·Aquaculture

Aquaculture

DOI: 10.1016/j.bcp.2023.115682

Activation of transient receptor potential channels is involved in reactive oxygen species (ROS)-dependent regulation of blood flow by (-)-epicatechin tetramer cinnamtannin A2.

Orally administered procyanidin-derived reactive oxygen species can activate TRP channels in gastrointestinal sensory nerves, triggering sympathetic hyperactivation and hemodynamic changes.

2023·2citations·Taiki Fushimi et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1016/j.intimp.2022.108920

Dexmedetomidine attenuates lipopolysaccharide-induced inflammation through macrophageal IL-10 expression following α7 nAchR activation.

Dexmedetomidine reduces inflammation in lipopolysaccharide-induced mice by increasing macrophage IL-10 expression, following activation of 7 nicotinic acetylcholine receptors, but not 2 -adrenoceptors.

2022·6citations·Qiao-Qiao Han et al.·International immunopharmacology

International immunopharmacology

DOI: 10.1097/FBP.0000000000000685

Acute glucagon-like peptide-1 receptor agonist liraglutide prevents cue-, stress-, and drug-induced heroin-seeking in rats

Liraglutide effectively prevents heroin-seeking in rats when administered acutely, potentially serving as a nonopioid bridge to treatment for opioid addiction.

2022·10citations·J. E. Douton et al.·Behavioural Pharmacology

Behavioural Pharmacology

DOI: 10.3389/fpsyt.2022.851296

Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

Guanfacine improves spatial memory and reduces hyperactivity in dopamine transporter knockout rats, potentially benefiting ADHD patients.

2022·7citations·N. Kurzina et al.·Frontiers in Psychiatry

Frontiers in Psychiatry