Zacopride: anxiolytic profile in rodent and primate models of anxiety

doi:10.1111/j.2042-7158.1988.tb05254.x

Paper

Zacopride: anxiolytic profile in rodent and primate models of anxiety

Published Apr 1, 1988 · Brenda Costall, A. Domeney, P. A. Gerrard

Journal of Pharmacy and Pharmacology

Q2 SJR score

171

Citations

7

Influential Citations

Full textSemantic Scholar

Abstract

Abstract— Zacopride, a substituted benzamide derivative, was compared with diazepam in three models of experimental or provoked anxiety. The drug's action (i) in reducing aversion to a brightly lit environment was assessed in mice using a two compartment black and white test box system, (ii) in disinhibiting a suppressed behaviour was measured in the rat social interaction test under high light/unfamiliar conditions and (iii) in antagonizing a defensive response in the marmoset was assessed using the threat of a human presence. Both zacopride and diazepam enhanced exploratory behaviour and social interaction in the mouse and rat models and antagonized the defensive response in the marmoset, zacopride being 100 times more potent than diazepam. It is concluded that the 5‐HT3 receptor antagonist, zacopride, alters rodent and primate behaviour in a manner consistent with that of an anxiolytic agent.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Zacopride, a 5HT3 receptor antagonist, enhances exploratory behavior and social interaction in rodent and primate models of anxiety, with a 100 times more potent effect than diazepam.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Zacopride: anxiolytic profile in rodent and primate models of anxiety

References

Citations