800mg gabapentin
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Effects and Efficacy of 800mg Gabapentin in Various Clinical Settings
Gabapentin 800mg in Postoperative Analgesia
Arthroscopic Shoulder Surgery
A study investigated whether a single preoperative dose of 800mg gabapentin could enhance postoperative analgesia in patients undergoing arthroscopic shoulder surgery with interscalene brachial plexus blocks. The results showed no significant differences in pain scores, analgesic requirements, or side effects between the gabapentin and placebo groups, except for a lower incidence of headaches in the gabapentin group1.
Total Knee Arthroplasty
In another study, the administration of 800mg gabapentin before total knee arthroplasty did not significantly reduce postoperative pain or analgesic requirements. However, it did attenuate the production of the inflammatory cytokine IL-6 on the first postoperative day, suggesting some anti-inflammatory benefits4.
Gabapentin 800mg for Preoperative Anxiolysis and Stress Response
Comparison with Clonidine
A comparative study evaluated the effects of 800mg gabapentin and 300µg clonidine on preoperative anxiolysis and the stress response to endotracheal intubation. The results indicated that clonidine was more effective than gabapentin in reducing anxiety and attenuating the stress response2.
Gabapentin 800mg in Anxiety Management
Simulated Public Speaking
Gabapentin at a dose of 800mg was found to attenuate anxiety induced by simulated public speaking. Participants reported decreased anxiety and hostility, indicating the anxiolytic potential of gabapentin6.
Gabapentin 800mg in Myoclonus Prevention
Etomidate-Induced Myoclonus
Pretreatment with 800mg gabapentin significantly reduced the incidence and severity of myoclonic movements associated with etomidate injection. This dose also increased the level of sedation compared to placebo5.
Bioequivalence and Pharmacokinetics
Switchability of Gabapentin Formulations
A study on the bioequivalence of 800mg gabapentin tablets (Neurontin and Gabasandoz) demonstrated that these formulations could be substituted without affecting clinical outcomes. The within-subject variability was minimal, supporting the switchability of these products3.
Conclusion
Gabapentin at a dose of 800mg has been studied across various clinical scenarios with mixed results. While it does not significantly enhance postoperative analgesia in some surgeries, it shows potential in reducing inflammatory cytokine production and managing anxiety. Additionally, it effectively reduces etomidate-induced myoclonus and is bioequivalent across different formulations, making it a versatile option in clinical practice.
Sources and full results
Most relevant research papers on this topic
A Single Preoperative Dose of Gabapentin (800 Milligrams) Does Not Augment Postoperative Analgesia in Patients Given Interscalene Brachial Plexus Blocks for Arthroscopic Shoulder Surgery
A single preoperative dose of 800 mg gabapentin does not augment postoperative analgesia in patients receiving interscalene brachial plexus blocks for arthroscopic shoulder surgery.
RCT
Highly CitedA RANDOMISED COMPARITIVE STUDY OF EFFECTS OF ORAL GABAPENTIN AND ORAL CLONIDINE ON PRE - OPERATIVE ANXIOLYSIS AND ATTENUATION OF STRESS RESPONSE TO ENDOTRACHEAL INTUBATION
Oral clonidine (300g) provided better anxiolysis and attenuation of stress response to endotracheal intubation than oral Gabapentin (800mg) when used for premedication in patients undergoing elective surgery.
RCTSwitchability of Gabapentin Formulations: A Randomized Trial to Assess Bioequivalence Between Neurontin and Gabasandoz on the Individual Subject Level
Substitution of gabapentin 800 mg tablets between Neurontin and Gabasandoz is possible without affecting clinical outcomes.
RCT
Rigorous JournalDoes preemptive gabapentin modulate cytokine response in total knee arthroplasty? A placebo controlled study.
Preemptive oral gabapentin administration did not reduce postoperative pain and analgesic requirements in total knee arthroplasty, but it attenuated IL-6 production on the first postoperative day.
RCT[Effect of gabapentin pretreatment on myoclonus after etomidate: a randomized, double-blind, placebo-controlled study].
Pretreatment with 800mg and 1200mg gabapentin before surgery increased sedation and reduced the incidence and severity of myoclonic movements due to etomidate.
RCTEffects of Gabapentin on Anxiety Induced by Simulated Public Speaking
Gabapentin at 800 mg effectively reduces anxiety and hostility in simulated public speaking, suggesting an anxiolytic potential.
Non-RCTClinical pharmacokinetics of gabapentin
Gabapentin is a rapidly absorbed, dose-dependent antiepileptic drug with unique pharmacokinetic properties, making it a promising alternative to standard antiepileptic drugs and oral contraceptives.
Highly CitedGabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study
Gabapentin is an effective and well-tolerated treatment for postherpetic neuralgia, with common adverse events being dizziness and somnolence.
RCT
Large Human TrialHighly CitedA single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster
A single dose of oral gabapentin (900 mg) significantly reduces acute pain and allodynia in patients with herpes zoster, providing greater pain relief compared to placebo.
RCTHighly CitedGabapentin
Reducing gabapentin dosage to 100mg at night can significantly improve confusion and other symptoms in patients with suspected toxicity.
Case Report