Is Adaptogenic Herbs safe?

Introduction

Adaptogenic herbs are natural substances believed to help the body adapt to stress and exert a normalizing effect upon bodily processes. They are increasingly being studied for their potential benefits in various health conditions, including stress-related disorders and cancer chemotherapy-induced toxicity.

Key Insights

Neuroprotective and Cognitive Benefits:
- Adaptogens like Andrographis, Eleutherococcus, Rhodiola, and Schisandra have shown potential neuroprotective effects, improving cognitive functions and reducing chemotherapy-induced cognitive impairments .
Reduction of Chemotherapy-Induced Toxicity:
- Adaptogenic herbs such as Andrographis, Eleutherococcus, and their combinations have been found to mitigate the toxic effects of chemotherapy on liver, heart, and kidneys by regulating gene expression related to these organs .
Cytotoxicity and Cancer Treatment:
- While adaptogens did not reduce the cytotoxic effects of chemotherapy drugs, some, like Andrographis and Rhodiola, even potentiated these effects, suggesting they could enhance the efficacy of chemotherapy.
Stress and Immune System Modulation:
- Adaptogens like Ocimum sanctum, Azadirachta indica, and Withania somnifera have been shown to modulate stress responses and improve neurobehavioral, endocrinal, and immune functions in animal studies .
Safety and Side Effects:
- Adaptogens are generally considered safe and free of significant side effects, making them preferable over synthetic drugs for long-term use in managing stress and improving overall health .

Conclusion

Adaptogenic herbs appear to offer several health benefits, particularly in reducing stress, enhancing cognitive functions, and mitigating the toxic effects of chemotherapy without compromising its efficacy. They are generally safe for long-term use, making them a viable option for improving quality of life and managing stress-related disorders. Further research and clinical trials are needed to fully understand their mechanisms and optimize their use in various health conditions.

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Is Adaptogenic Herbs safe?

Summary

Consensus Meter

Introduction

Key Insights

Conclusion

Sources and full results

Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells.

Adaptogenic herbal extracts, such as andrographolide and Eleutherococcus roots, can reduce cancer chemotherapy-induced toxicity and increase survival by promoting cell survival and DNA repair.

Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells.

Adaptogenic plant extracts, such as andrographolide and rhodiola, did not significantly reduce the cytotoxic effects of chemotherapy on neuroglia cells, and AP and RSE may have potentiated them.

Deconstructing an Adaptogen: Eleutherococcus senticosus

Eleutherococcus senticosus, a potential adaptogen, supports health and prevents disease through nonspecific effects, neutralizing environmental and physical stressors while remaining relatively safe and free of side effects.

Adaptogenic effects of some medicinal plants: Integration of traditional and modern concepts

Adaptogenic effects of medicinal plants like Ocimum sanctum, Azadirachta indica, and Ashwagandha can be influenced by CNS-neuroendocrine-immune interactions, potentially leading to new, more effective, and safer treatments for stress-related disorders.

Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells.

Adaptogenic plant extracts, such as Andrographis paniculata and Eleutherococcus root, may help reduce cognitive impairments in cancer chemotherapy by promoting neuronal functions.

Systemic and Anticancer Potential of Adaptogenic Constituents Isolated from Traditional Herbs - A Mini-Review.

Adaptogens isolated from traditional herbs show potential as effective chemopreventive agents and systemic effects, offering potential for personalized cancer treatment and chemoprevention in the future.

Biomolecules from Plants as an Adaptogen

Adaptogens, which are plant-derived biomolecules, help maintain internal homeostasis and combat stress-related diseases by maintaining internal homeostasis and exhibiting neuro-protective, anxiolytic, anti-fatigue, nootropic, anti-depressive, and CNS stimulating activities.

Supporting Adrenal Function with Adaptogenic Herbs

Adaptogenic herbs, such as Eleuthero Root, Holy Basil, and Rhodiola, can enhance energy production, sleep quality, and immune function, supporting adrenal function and promoting stress adaptation.

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Adaptogenic plants promote adaptability, resilience, and survival in stress, offering potential for treating stress-induced and aging-related disorders.

A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide

Adaptogens, found in traditional Chinese medicine and worldwide ginseng-like herbs, enhance human resistance to stress by affecting the immune-neuro-endocrine system and hypothalamic-pituitary-adrenal axis.

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