10 papers analyzed
These studies suggest that adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with poor prognosis, limited treatment options, and ongoing research into targeted therapies and diagnostic improvements.
Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy originating from the adrenal cortex. It is characterized by a poor prognosis and a complex pathogenesis that is not yet fully understood. The disease often presents with hormone excess or as a large abdominal mass, and its treatment remains challenging due to limited effective therapeutic options.
Pathogenesis and Molecular Mechanisms:
Clinical Presentation and Diagnosis:
Prognosis and Survival:
Treatment Strategies:
Challenges and Future Directions:
Adrenocortical carcinoma is a rare and aggressive cancer with a poor prognosis. Key molecular pathways involved in its pathogenesis include IGF-2 overexpression and Wnt/β-catenin activation. The disease often presents with hormone excess or as a large abdominal mass, and comprehensive hormonal and imaging assessments are essential for diagnosis. Surgery remains the primary treatment for localized disease, while mitotane is the cornerstone of adjuvant and metastatic treatment. Despite these strategies, the overall survival rate remains low, highlighting the need for continued research and the development of new targeted therapies. Collaborative international efforts are essential to improve understanding and treatment of this challenging malignancy.
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