Amlodipine and hair loss
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Amlodipine and Hair Loss: An Overview
Introduction to Amlodipine
Amlodipine is a long-acting calcium channel blocker commonly prescribed for the treatment of hypertension and angina. It works by relaxing blood vessels, allowing blood to flow more easily, and reducing the workload on the heart.
Case Study: Frontal Fibrosing Alopecia and Amlodipine
A case study involving a 47-year-old postmenopausal woman highlighted a potential link between amlodipine use and hair loss. The patient experienced significant hair loss in the frontal region of the scalp over a year, coinciding with the use of amlodipine and atenolol for hypertension. Clinical examination revealed a 2-cm band of recession along the frontotemporal hairline, with smooth, shiny, and atrophic skin, and absence of follicular orifices in the affected areas. Despite the hair loss, the patient did not report any history of hair manipulation or cosmetic practices that could explain the condition.
Experimental Study: Hair Loss in Rats
An experimental study on adult male Wistar rats further supports the potential association between amlodipine and hair loss. Rats administered varying doses of amlodipine (5-40 mg/kg body weight) over 56-65 days exhibited dose-dependent hair loss, along with other symptoms such as reduced body weight and loss of locomotion and balance. These findings suggest that prolonged use of amlodipine may contribute to hair loss, at least in animal models.
Conclusion
While direct evidence linking amlodipine to hair loss in humans is limited, the case study and experimental research indicate a potential association. Patients experiencing unexplained hair loss while on amlodipine should consult their healthcare provider to discuss possible alternatives or additional treatments. Further research is needed to establish a definitive causal relationship and understand the underlying mechanisms.
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