Best medicine for allergy itchy skin
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Best Medicine for Allergy Itchy Skin
Traditional Chinese Medicine (TCM) for Allergy and Eczema
Traditional Chinese Medicine (TCM) has shown promise in treating food allergies and eczema, which often present with itchy skin. Notably, the Food Allergy Herbal Formula 2 (FAHF-2) has demonstrated safety and preliminary immunomodulatory effects in murine models, preventing systemic anaphylaxis and showing potential in human trials1. Additionally, comprehensive TCM therapy, including ingestion, baths, and creams, has markedly improved skin lesions, itching, and sleep loss in patients with severe eczema1. Acupuncture, another TCM practice, has also been effective in reducing skin itching and basophil activation in atopic dermatitis1.
Mastic Resin for Allergic Dermatitis
Mastic, a natural resin from Pistacia lentiscus, has been studied for its anti-inflammatory and anti-pruritic properties. In mouse models of allergic contact dermatitis, topical application of mastic significantly reduced ear swelling, itch behavior, and pro-inflammatory cytokine production2. These findings suggest that mastic could be a beneficial topical treatment for managing itchy skin associated with allergic dermatitis.
Anti-Itch Therapy in Allergic Dermatoses
The treatment of itch in allergic dermatoses, such as atopic dermatitis and eczema, involves a multi-faceted approach. Systemic treatments include antihistamines, glucocorticosteroids, and leukotriene receptor antagonists, while topical treatments involve emollients, topical glucocorticosteroids, and calcineurin inhibitors3. This comprehensive approach aims to control both local and systemic mechanisms of allergic inflammation, providing relief from itching3.
Qingpeng Ointment for Allergic Contact Dermatitis
Qingpeng ointment, a traditional Tibetan medicine, has been effective in treating allergic contact dermatitis. It works by suppressing the production of Th1/2 cytokines and itch-related genes, thereby reducing scratching behavior and inflammation in mouse models5. This ointment also inhibits the phosphorylation of MAPKs, which are involved in the inflammatory response, making it a potent anti-pruritic treatment5.
Efficacy of Montelukast and Loratadine
Montelukast, an antileukotriene agent, and loratadine, an antihistamine, have been evaluated for their effects on skin reactivity. Both medications significantly reduced itching in skin prick tests, with loratadine also reducing wheal and flare reactions7. These findings indicate that both montelukast and loratadine can be effective in managing itchy skin associated with allergic reactions7.
Conclusion
In summary, various treatments have shown efficacy in managing itchy skin due to allergies. Traditional Chinese Medicine, including herbal formulas and acupuncture, offers promising results for eczema and food allergies. Natural products like mastic resin provide anti-inflammatory and anti-pruritic benefits. Comprehensive anti-itch therapy for allergic dermatoses involves both systemic and topical treatments. Qingpeng ointment and medications like montelukast and loratadine also play significant roles in alleviating itch. Further research and clinical trials are necessary to optimize these treatments and confirm their long-term safety and efficacy.
Sources and full results
Most relevant research papers on this topic
Traditional Chinese Medicine for Food Allergy and Eczema.
Traditional Chinese medicine shows potential as a safe and effective therapy for food allergy and eczema, with potential for further research on botanical drug development and mechanisms of actions.
Systematic ReviewTopical treatment with mastic (resin from Pistacia lentiscus) elicits anti-inflammatory and anti-pruritic responses by modulating keratinocyte activation in a mouse model of allergic dermatitis.
Topical treatment with mastic significantly reduces inflammation and pruritus in a mouse model of allergic dermatitis, offering a potential alternative to traditional treatments.
Non-RCT
Animal Study
Rigorous JournalFeatures of pathogenesis of itch and anti0itch therapy in children with allergic dermatosis (literature review)
Anti-itch therapy in children with allergic dermatoses should be individualized and based on etiopathogenetic principles, addressing local and systemic mechanisms of allergic inflammation.
Literature ReviewApplication of topical corticosteroids to sites of positive immediate-type allergy skin tests to relieve itching: results of a double-blind, placebo-controlled trial.
Topical corticosteroid cream applied to sites of positive immediate-type allergy skin tests does not provide relief of itching, and patients should be informed that itching will resolve within 30 minutes without needing such treatment.
RCTQingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Qingpeng ointment effectively reduces inflammation and itch-related symptoms in allergic contact dermatitis by inhibiting Th1/2 cytokines and itch-related genes.
Non-RCTAnimal StudyEfficacy of Chinese herbal medicine on nasal itching in children with allergic rhinitis: a systematic review and meta-analysis
Chinese herbal medicine, alone or combined with Western medicine, effectively reduces nasal itching in children with allergic rhinitis.
Meta-AnalysisThe effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests.
Montelukast tends to suppress flare and itching in skin prick tests, but not wheal size, with little impact on the clinical effectiveness of skin prick tests as a diagnostic tool.
RCTCalcium preparations do not inhibit allergic reactions: a randomized controlled trial.
Calcium preparations do not effectively inhibit allergic reactions, and their use in allergic patients should be discouraged due to potential interference with antiallergic drug absorption.
RCTNew and Emerging Treatments for Inflammatory Itch.
Recent therapeutic developments for chronic pruritus, focusing on allergic and type 2 inflammatory pathways, have revolutionized treatment for atopic dermatitis and prurigo nodularis.
Systematic ReviewDrug hypersensitivity to various antihistamines with cross-reactions: a case report
Antihistamines can cause drug hypersensitivity, causing itchy hives in patients with chronic urticaria, making it difficult to choose a safe treatment.
Case Report