Best Nad+ Supplement

Best NAD+ Supplement: A Comprehensive Review

Introduction to NAD+ Supplements

Nicotinamide adenine dinucleotide (NAD+) is a crucial coenzyme in the body, playing a significant role in energy metabolism and cellular function. As we age, NAD+ levels decline, which has been linked to various age-related conditions. Consequently, NAD+ supplementation has gained popularity as a potential anti-aging strategy. This article reviews the current research on the best NAD+ supplements, focusing on their efficacy, safety, and potential benefits.

Nicotinamide Riboside (NR): A Leading NAD+ Precursor

Efficacy of Nicotinamide Riboside

Nicotinamide riboside (NR) is one of the most studied NAD+ precursors. Research indicates that NR supplementation effectively increases NAD+ levels in humans. A study involving 120 healthy adults aged 60-80 showed that NR, combined with pterostilbene (NRPT), significantly increased NAD+ levels by 40% with a regular dose and 90% with a double dose over eight weeks. Another study confirmed that chronic NR supplementation is well-tolerated and effectively elevates NAD+ levels in middle-aged and older adults.

Health Benefits of Nicotinamide Riboside

NR supplementation has shown promise in enhancing oxidative metabolism and protecting against metabolic diseases. In animal models, NR increased NAD+ levels, activated sirtuins, and improved mitochondrial function, which protected against high-fat diet-induced obesity. In humans, NR supplementation has been associated with improved cardiovascular parameters, such as reduced blood pressure and arterial stiffness. Additionally, NR has demonstrated potential anti-inflammatory effects and benefits for skeletal muscle health in aged individuals.

Nicotinamide and Nicotinic Acid: Traditional NAD+ Precursors

Weight Management and Hormonal Effects

Nicotinamide and nicotinic acid are traditional NAD+ precursors that have been studied for their effects on weight management. A systematic review and meta-regression analysis of randomized controlled trials found that NAD+ precursor supplementation, particularly nicotinic acid, significantly reduced BMI and increased adiponectin levels, although it did not significantly affect body weight or leptin levels.

Cognitive Health

Nicotinamide and its derivatives have also been investigated for their potential to prevent cognitive decline. While most studies have been conducted in animal models, there is growing evidence that NAD+ precursors may help preserve cognitive function in age-related conditions such as Alzheimer's disease and vascular dementia.

Combination Supplements: Enhanced Efficacy

NRPT (Nicotinamide Riboside and Pterostilbene)

NRPT, commercially known as Basis, combines NR with pterostilbene, a polyphenol found in blueberries. This combination has been shown to significantly increase NAD+ levels in a dose-dependent manner, with sustained effects over an eight-week period. The combination of NR and pterostilbene may offer enhanced benefits due to the complementary effects of both compounds.

RiaGev (Nicotinamide and D-Ribose)

RiaGev is another combination supplement that includes nicotinamide and D-ribose. A pilot clinical trial demonstrated that RiaGev significantly increased the NAD+ metabolome, improved insulin sensitivity, and reduced fatigue and mental concentration issues in healthy middle-aged adults. This combination appears to be safe and effective for enhancing NAD+ levels and related metabolic benefits.

Safety and Future Research

While NAD+ precursors like NR, nicotinamide, and nicotinic acid have shown promising results, there are still uncertainties regarding the optimal dosage, long-term safety, and potential side effects. More clinical trials are needed to determine the best approaches and combinations for increasing NAD+ levels safely and effectively.

Conclusion

Nicotinamide riboside (NR) stands out as a leading NAD+ supplement due to its proven efficacy in increasing NAD+ levels and its potential health benefits. Combination supplements like NRPT and RiaGev may offer enhanced effects. However, further research is necessary to establish the long-term safety and optimal usage of these supplements. As the interest in NAD+ boosting strategies continues to grow, ongoing studies will help refine our understanding and application of these promising compounds.

Summary

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