Blood pressure cough
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Summary
10 papers analyzed
These studies suggest that blood pressure influences cough frequency and duration, with elevated blood pressure reducing coughs and reduced blood pressure increasing them, and that certain antihypertensive medications like eprosartan and losartan are associated with fewer cough symptoms.
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Blood Pressure and Cough: Interconnected Mechanisms and Clinical Implications
Influence of Blood Pressure on Cough Reflex
Baroreceptor Modulation of Cough Reflex
Research indicates that systemic arterial blood pressure (BP) significantly influences the excitability and motor pattern of the cough reflex. Elevated BP has been shown to suppress coughing by stimulating arterial baroreceptors, which in turn modulate respiratory neurons within the brainstem. This suppression is characterized by a reduction in cough number, inspiratory and expiratory amplitudes, and prolongation of the cough cycle duration. Conversely, reduced BP increases cough frequency and intensity, suggesting a complex interaction between barosensitive and respiratory brainstem networks.
Cough Syncope and Blood Pressure Dynamics
Cough-Induced Hypotension and Bradycardia
Cough syncope, a condition where coughing leads to fainting, is associated with profound hypotension and an inappropriate chronotropic response. Patients with cough syncope exhibit a greater drop in systolic pressure and a longer recovery time compared to other fainters. This condition is marked by a diminished heart rate response to cough-induced hypotension, supporting the notion of a neurally mediated reflex contributing to symptomatic hypotension in these patients .
Therapeutic Interventions and Device Applications
Functional Electrical Stimulation (FES) for Tetraplegic Patients
In tetraplegic patients, particularly those dependent on ventilators, functional electrical stimulation (FES) of the abdominal muscles has been shown to effectively control postural hypertension and augment cough. This intervention significantly improves blood pressure maintenance and enhances cough efficacy, thereby improving the quality of life for these patients.
Pharmacological Comparisons: Eprosartan vs. Enalapril
Impact on Cough and Blood Pressure
Comparative studies between eprosartan, an angiotensin receptor antagonist, and enalapril, an angiotensin-converting enzyme inhibitor, reveal that eprosartan is associated with a lower incidence of cough while effectively reducing blood pressure. Enalapril, although effective in lowering BP, is linked to a higher risk of persistent dry cough. These findings suggest that eprosartan may be a preferable option for hypertensive patients who experience cough as a side effect of enalapril .
Physiological Mechanisms: Cough and Blood Flow
Cough-Induced Hemodynamic Changes
Coughing can induce significant fluctuations in intrathoracic pressure, which in turn affects arterial pressure and peripheral blood flow. These rapid pressure changes, often compared to the Valsalva maneuver, can impose large amplitude transients on the cardiovascular system, influencing both arterial and venous pressure pulses. Such dynamics are crucial in understanding the systemic effects of coughing on blood flow and pressure .
Conclusion
The interplay between blood pressure and cough reflex is multifaceted, involving neural, mechanical, and pharmacological factors. Elevated or reduced BP can modulate cough reflex intensity and duration, while conditions like cough syncope highlight the critical role of neural reflexes in BP regulation during coughing. Therapeutic interventions, including FES and specific antihypertensive medications, offer promising avenues for managing the complex interactions between blood pressure and cough. Understanding these mechanisms is essential for optimizing treatment strategies and improving patient outcomes.
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