Blood pressure medication beginning with l
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Blood Pressure Medications Beginning with "L"
Losartan: Effective Combination Therapy
Losartan and Hydrochlorothiazide Combination
Losartan, often combined with hydrochlorothiazide (HCTZ), has been shown to be highly effective in managing hypertension. A study compared the efficacy of initiating therapy with a combination of losartan (L) and HCTZ versus a stepped-care approach in patients with stage 2 or 3 hypertension. The results indicated that significantly more patients achieved the target blood pressure (BP) with the losartan/HCTZ combination compared to the stepped-care approach. Additionally, the combination therapy led to faster BP control, fewer medications, and fewer adverse events1.
L-Arginine: Supplementation for Blood Pressure Control
Meta-Analysis of L-Arginine Supplementation
L-Arginine, an amino acid, has been studied for its potential BP-lowering effects. A meta-analysis of randomized, double-blind, placebo-controlled trials found that oral L-Arginine supplementation significantly lowered both systolic and diastolic BP. The analysis included 11 trials with 387 participants, showing a reduction in systolic BP by 5.39 mm Hg and diastolic BP by 2.66 mm Hg compared to placebo2.
L-Arginine in Pregnant Women with Chronic Hypertension
In pregnant women with chronic hypertension, L-Arginine supplementation was evaluated for its impact on BP and maternal and neonatal complications. Although the BP changes were not significantly different between the L-Arginine and placebo groups, fewer women in the L-Arginine group required antihypertensive medications. There was also a trend towards fewer maternal and neonatal complications in the L-Arginine group, suggesting potential benefits in high-risk pregnancies6.
Lercanidipine: Efficacy in Elderly Patients
Lercanidipine and Enalapril Combination
Lercanidipine, a calcium channel blocker, has been studied in combination with enalapril for treating hypertension in elderly patients. A placebo-controlled, randomized crossover study found that the combination of lercanidipine and enalapril significantly reduced both ambulatory and office BP compared to either drug alone. The combination therapy was also well tolerated, with a higher percentage of patients achieving target BP levels4.
Lisinopril: Combination Therapy with Hydrochlorothiazide
Lisinopril and Hydrochlorothiazide Combination
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is often combined with hydrochlorothiazide for enhanced antihypertensive effects. A large multicenter study demonstrated that the combination of lisinopril and hydrochlorothiazide was more effective in lowering BP compared to either drug alone. The combination therapy also showed a favorable safety profile, with minimal metabolic side effects5.
Conclusion
Medications beginning with "L," such as losartan, L-Arginine, lercanidipine, and lisinopril, have demonstrated significant efficacy in managing hypertension. Combination therapies involving these medications often result in better BP control, fewer medications, and improved tolerability. These findings highlight the importance of tailored antihypertensive strategies to achieve optimal patient outcomes.
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Most relevant research papers on this topic
Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension.
Initiating antihypertensive therapy with a combination of losartan and hydrochlorothiazide leads to faster blood pressure control, fewer adverse events, and less need for a third drug regimen compared to the conventional stepped-care approach.
RCTEffect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials.
Oral L-arginine supplementation significantly lowers both systolic and diastolic blood pressure compared to placebo in randomized, double-blind, placebo-controlled trials.
Meta-Analysis
Highly CitedInitial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial
A single pill containing ultra-low-dose quadruple combination therapy is more effective than standard dose monotherapy in reducing systolic blood pressure in patients with hypertension.
RCT
Large Human Trial
Rigorous JournalHighly CitedLercanidipine, enalapril and their combination in the treatment of elderly hypertensive patients: placebo-controlled, randomized, crossover study with four ABPM
Combination therapy with lercanidipine and enalapril effectively reduces both ambulatory and office blood pressure in elderly patients and is well-tolerated.
RCTRigorous JournalAntihypertensive effectiveness of low-dose lisinopril-hydrochlorothiazide combination. A large multicenter study. Lisinopril-Hydrochlorothiazide Group.
Low-dose lisinopril-hydrochlorothiazide combination effectively reduces blood pressure and is well-tolerated, with the best results achieved with L/H12.5 and L/H25.
RCTl-Arginine supplementation in women with chronic hypertension: impact on blood pressure and maternal and neonatal complications
L-arginine supplementation in pregnant women with mild chronic hypertension does not significantly affect blood pressure but is associated with less need for antihypertensive medications and a trend toward fewer maternal and neonatal complications.
RCTL-arginine prevents corticotropin-induced increases in blood pressure in the rat.
L-arginine effectively prevents corticotropin-induced increases in blood pressure in Sprague-Dawley rats, but not D-arginine, suggesting its effects are not solely due to decreased corticosterone secretion.
RCT
Animal StudyHighly CitedEffect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trials
L-citrulline supplementation significantly reduces non-resting brachial and aortic blood pressure, with stronger effects for brachial DBP regardless of resting status.
Meta-AnalysisRigorous JournalThe influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure.
BPC 157 can interfere with nitric oxide effects on gastric mucosal integrity and blood pressure maintenance, potentially benefiting both gastric health and blood pressure maintenance.
Non-RCTAnimal StudyHighly CitedControlled multicentre comparison of captopril versus lisinopril in the treatment of mild-to-moderate arterial hypertension.
Lisinopril and captopril show comparable efficacy and safety in treating mild-to-moderate arterial hypertension, with lisinopril being slightly more potent and longer acting.
RCT